Cargando…
SARS-CoV-2 antibody response duration and neutralization following natural infection
BACKGROUND: The role of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) neutralizing antibody response from natural infection and vaccination, and the potential determinants of this response are poorly understood. Characterizing this antibody response and the factors associated with...
Autores principales: | , , , , , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10470471/ https://www.ncbi.nlm.nih.gov/pubmed/37654784 http://dx.doi.org/10.1016/j.jcvp.2023.100158 |
_version_ | 1785099684984913920 |
---|---|
author | Dukes, Christopher W Rossetti, Renata AM Hensel, Jonathan A Snedal, Sebastian Cubitt, Christopher L Schell, Michael J Abrahamsen, Martha Isaacs-Soriano, Kimberly Kennedy, Kayoko Mangual, Leslie N Whiting, Junmin Martinez-Brockhus, Veronica Islam, Jessica Y Rathwell, Julie Beatty, Matthew Hall, Amy M Abate-Daga, Daniel Giuliano, Anna R Pilon-Thomas, Shari |
author_facet | Dukes, Christopher W Rossetti, Renata AM Hensel, Jonathan A Snedal, Sebastian Cubitt, Christopher L Schell, Michael J Abrahamsen, Martha Isaacs-Soriano, Kimberly Kennedy, Kayoko Mangual, Leslie N Whiting, Junmin Martinez-Brockhus, Veronica Islam, Jessica Y Rathwell, Julie Beatty, Matthew Hall, Amy M Abate-Daga, Daniel Giuliano, Anna R Pilon-Thomas, Shari |
author_sort | Dukes, Christopher W |
collection | PubMed |
description | BACKGROUND: The role of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) neutralizing antibody response from natural infection and vaccination, and the potential determinants of this response are poorly understood. Characterizing this antibody response and the factors associated with neutralization can help inform future prevention efforts and improve clinical outcomes in those infected. OBJECTIVES: The goals of this study were to prospectively evaluate SARS-CoV-2 antibody levels and the neutralizing antibody responses among naturally infected adults and to determine demographic and behavioral factors independently associated with these responses. METHODS: Serum was collected from seropositive individuals at baseline, four-weeks, and three-months following their first study visit to be evaluated for antibody levels. Detection of neutralizing antibodies was performed at baseline. Participant demographic and behavioral information was collected via web questionnaire prior to their first visit. RESULTS: At baseline, higher antibody levels were associated with better neutralization capacity, with 83% of participants having detectable neutralizing antibodies. We found an age-dependent effect on antibody level and neutralization capacity with participants over 65 years having significantly higher levels. Ethnicity, heart disease, autoimmune disease, and COVID symptoms were associated with higher antibody levels, but not with increased neutralization capacity. Work environment during the pandemic correlated with increased neutralization capacity, while kidney or liver disease and traveling out of state after February 2020 correlated with decreased neutralization capacity, however neither correlated with antibody levels. CONCLUSIONS: Our data show that natural infection by SARS-CoV-2 can induce a humoral response reflected by high antibody levels and neutralization capacity. |
format | Online Article Text |
id | pubmed-10470471 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
record_format | MEDLINE/PubMed |
spelling | pubmed-104704712023-08-31 SARS-CoV-2 antibody response duration and neutralization following natural infection Dukes, Christopher W Rossetti, Renata AM Hensel, Jonathan A Snedal, Sebastian Cubitt, Christopher L Schell, Michael J Abrahamsen, Martha Isaacs-Soriano, Kimberly Kennedy, Kayoko Mangual, Leslie N Whiting, Junmin Martinez-Brockhus, Veronica Islam, Jessica Y Rathwell, Julie Beatty, Matthew Hall, Amy M Abate-Daga, Daniel Giuliano, Anna R Pilon-Thomas, Shari J Clin Virol Plus Article BACKGROUND: The role of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) neutralizing antibody response from natural infection and vaccination, and the potential determinants of this response are poorly understood. Characterizing this antibody response and the factors associated with neutralization can help inform future prevention efforts and improve clinical outcomes in those infected. OBJECTIVES: The goals of this study were to prospectively evaluate SARS-CoV-2 antibody levels and the neutralizing antibody responses among naturally infected adults and to determine demographic and behavioral factors independently associated with these responses. METHODS: Serum was collected from seropositive individuals at baseline, four-weeks, and three-months following their first study visit to be evaluated for antibody levels. Detection of neutralizing antibodies was performed at baseline. Participant demographic and behavioral information was collected via web questionnaire prior to their first visit. RESULTS: At baseline, higher antibody levels were associated with better neutralization capacity, with 83% of participants having detectable neutralizing antibodies. We found an age-dependent effect on antibody level and neutralization capacity with participants over 65 years having significantly higher levels. Ethnicity, heart disease, autoimmune disease, and COVID symptoms were associated with higher antibody levels, but not with increased neutralization capacity. Work environment during the pandemic correlated with increased neutralization capacity, while kidney or liver disease and traveling out of state after February 2020 correlated with decreased neutralization capacity, however neither correlated with antibody levels. CONCLUSIONS: Our data show that natural infection by SARS-CoV-2 can induce a humoral response reflected by high antibody levels and neutralization capacity. 2023-08 2023-07-01 /pmc/articles/PMC10470471/ /pubmed/37654784 http://dx.doi.org/10.1016/j.jcvp.2023.100158 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ). |
spellingShingle | Article Dukes, Christopher W Rossetti, Renata AM Hensel, Jonathan A Snedal, Sebastian Cubitt, Christopher L Schell, Michael J Abrahamsen, Martha Isaacs-Soriano, Kimberly Kennedy, Kayoko Mangual, Leslie N Whiting, Junmin Martinez-Brockhus, Veronica Islam, Jessica Y Rathwell, Julie Beatty, Matthew Hall, Amy M Abate-Daga, Daniel Giuliano, Anna R Pilon-Thomas, Shari SARS-CoV-2 antibody response duration and neutralization following natural infection |
title | SARS-CoV-2 antibody response duration and neutralization following natural infection |
title_full | SARS-CoV-2 antibody response duration and neutralization following natural infection |
title_fullStr | SARS-CoV-2 antibody response duration and neutralization following natural infection |
title_full_unstemmed | SARS-CoV-2 antibody response duration and neutralization following natural infection |
title_short | SARS-CoV-2 antibody response duration and neutralization following natural infection |
title_sort | sars-cov-2 antibody response duration and neutralization following natural infection |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10470471/ https://www.ncbi.nlm.nih.gov/pubmed/37654784 http://dx.doi.org/10.1016/j.jcvp.2023.100158 |
work_keys_str_mv | AT dukeschristopherw sarscov2antibodyresponsedurationandneutralizationfollowingnaturalinfection AT rossettirenataam sarscov2antibodyresponsedurationandneutralizationfollowingnaturalinfection AT henseljonathana sarscov2antibodyresponsedurationandneutralizationfollowingnaturalinfection AT snedalsebastian sarscov2antibodyresponsedurationandneutralizationfollowingnaturalinfection AT cubittchristopherl sarscov2antibodyresponsedurationandneutralizationfollowingnaturalinfection AT schellmichaelj sarscov2antibodyresponsedurationandneutralizationfollowingnaturalinfection AT abrahamsenmartha sarscov2antibodyresponsedurationandneutralizationfollowingnaturalinfection AT isaacssorianokimberly sarscov2antibodyresponsedurationandneutralizationfollowingnaturalinfection AT kennedykayoko sarscov2antibodyresponsedurationandneutralizationfollowingnaturalinfection AT mangualleslien sarscov2antibodyresponsedurationandneutralizationfollowingnaturalinfection AT whitingjunmin sarscov2antibodyresponsedurationandneutralizationfollowingnaturalinfection AT martinezbrockhusveronica sarscov2antibodyresponsedurationandneutralizationfollowingnaturalinfection AT islamjessicay sarscov2antibodyresponsedurationandneutralizationfollowingnaturalinfection AT rathwelljulie sarscov2antibodyresponsedurationandneutralizationfollowingnaturalinfection AT beattymatthew sarscov2antibodyresponsedurationandneutralizationfollowingnaturalinfection AT hallamym sarscov2antibodyresponsedurationandneutralizationfollowingnaturalinfection AT abatedagadaniel sarscov2antibodyresponsedurationandneutralizationfollowingnaturalinfection AT giulianoannar sarscov2antibodyresponsedurationandneutralizationfollowingnaturalinfection AT pilonthomasshari sarscov2antibodyresponsedurationandneutralizationfollowingnaturalinfection |