Influenza H3 hemagglutinin vaccine with scrambled immunodominant epitopes elicits antibodies directed toward immunosubdominant head epitopes

Vaccination is the most effective countermeasure to reduce the severity of influenza. Current seasonal influenza vaccines mainly elicit humoral immunity targeting hemagglutinin (HA). In particular, the amino acid residues around the receptor-binding site in the HA head domain are predominantly targe...

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Detalles Bibliográficos
Autores principales: Chiba, Shiho, Kong, Huihui, Neumann, Gabriele, Kawaoka, Yoshihiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10470489/
https://www.ncbi.nlm.nih.gov/pubmed/37466314
http://dx.doi.org/10.1128/mbio.00622-23

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10470489/
https://www.ncbi.nlm.nih.gov/pubmed/37466314
http://dx.doi.org/10.1128/mbio.00622-23

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