The hows and whys of amastigote flagellum motility in Trypanosoma cruzi

The protist Trypanosoma cruzi exhibits several extracellular stages characterized by the presence of a long and motile flagellum and one intracellular life cycle stage termed amastigote, which possesses a tiny flagellum barely exiting the flagellar pocket. This stage was so far described as replicat...

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Detalles Bibliográficos
Autores principales: Alves, Aline Araujo, Bastin, Philippe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2023
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10470501/
https://www.ncbi.nlm.nih.gov/pubmed/37278521
http://dx.doi.org/10.1128/mbio.00531-23
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author Alves, Aline Araujo
Bastin, Philippe
author_facet Alves, Aline Araujo
Bastin, Philippe
author_sort Alves, Aline Araujo
collection PubMed
description The protist Trypanosoma cruzi exhibits several extracellular stages characterized by the presence of a long and motile flagellum and one intracellular life cycle stage termed amastigote, which possesses a tiny flagellum barely exiting the flagellar pocket. This stage was so far described as replicative but immotile cells. Unexpectedly, the recent work of M. M. Won, T. Krüger, M. Engstler, and B. A. Burleigh (mBio 14:e03556-22, 2023, https://doi.org/10.1128/mbio.03556-22) revealed that this short flagellum actually displays beating activity. This commentary explores how such a short flagellum could be constructed and why it could affect the parasite’s survival inside the mammalian host.
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spelling pubmed-104705012023-09-01 The hows and whys of amastigote flagellum motility in Trypanosoma cruzi Alves, Aline Araujo Bastin, Philippe mBio Commentary The protist Trypanosoma cruzi exhibits several extracellular stages characterized by the presence of a long and motile flagellum and one intracellular life cycle stage termed amastigote, which possesses a tiny flagellum barely exiting the flagellar pocket. This stage was so far described as replicative but immotile cells. Unexpectedly, the recent work of M. M. Won, T. Krüger, M. Engstler, and B. A. Burleigh (mBio 14:e03556-22, 2023, https://doi.org/10.1128/mbio.03556-22) revealed that this short flagellum actually displays beating activity. This commentary explores how such a short flagellum could be constructed and why it could affect the parasite’s survival inside the mammalian host. American Society for Microbiology 2023-06-06 /pmc/articles/PMC10470501/ /pubmed/37278521 http://dx.doi.org/10.1128/mbio.00531-23 Text en Copyright © 2023 Alves et al. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Commentary
Alves, Aline Araujo
Bastin, Philippe
The hows and whys of amastigote flagellum motility in Trypanosoma cruzi
title The hows and whys of amastigote flagellum motility in Trypanosoma cruzi
title_full The hows and whys of amastigote flagellum motility in Trypanosoma cruzi
title_fullStr The hows and whys of amastigote flagellum motility in Trypanosoma cruzi
title_full_unstemmed The hows and whys of amastigote flagellum motility in Trypanosoma cruzi
title_short The hows and whys of amastigote flagellum motility in Trypanosoma cruzi
title_sort hows and whys of amastigote flagellum motility in trypanosoma cruzi
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10470501/
https://www.ncbi.nlm.nih.gov/pubmed/37278521
http://dx.doi.org/10.1128/mbio.00531-23
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