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Establishment of a CPER reverse genetics system for Powassan virus defines attenuating NS1 glycosylation sites and an infectious NS1-GFP11 reporter virus

Powassan virus (POWV) is an emerging tick-borne Flavivirus that causes lethal encephalitis and long-term neurologic damage. Currently, there are no POWV therapeutics, licensed vaccines, or reverse genetics systems for producing infectious POWVs from recombinant DNA. Using a circular polymerase exten...

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Detalles Bibliográficos
Autores principales:	Conde, Jonas N., Himmler, Grace E., Mladinich, Megan C., Setoh, Yin Xiang, Amarilla, Alberto A., Schutt, William R., Saladino, Nicholas, Gorbunova, Elena E., Salamango, Daniel J., Benach, Jorge, Kim, Hwan Keun, Mackow, Erich R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10470542/ https://www.ncbi.nlm.nih.gov/pubmed/37489888 http://dx.doi.org/10.1128/mbio.01388-23

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