Toxoplasma gondii inhibits the expression of autophagy-related genes through AKT-dependent inactivation of the transcription factor FOXO3a

The intracellular parasite Toxoplasma gondii induces host AKT activation to prevent autophagy-mediated clearance; however, the molecular underpinnings are not fully understood. Autophagy can be negatively regulated through AKT-sensitive phosphorylation and nuclear export of the transcription factor...

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Detalles Bibliográficos
Autores principales: Diez, Andres Felipe, Leroux, Louis-Philippe, Chagneau, Sophie, Plouffe, Alexandra, Gold, Mackenzie, Chaparro, Visnu, Jaramillo, Maritza
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10470550/
https://www.ncbi.nlm.nih.gov/pubmed/37387601
http://dx.doi.org/10.1128/mbio.00795-23

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10470550/
https://www.ncbi.nlm.nih.gov/pubmed/37387601
http://dx.doi.org/10.1128/mbio.00795-23

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