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Economic Burden of Fatigue in Inflammatory Bowel Disease

BACKGROUND: This retrospective study gathered medical/pharmacy claims data on patients with inflammatory bowel disease (IBD) between January 01, 2000 and March 31, 2019 from the IBM MarketScan commercial claims database to assess the real-world impact of fatigue on healthcare costs in patients newly...

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Autores principales: Ananthakrishnan, Ashwin N, Desai, Raj, Lee, Wan-Ju, Griffith, Jenny, Chen, Naijun, Loftus, Edward V
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10470665/
https://www.ncbi.nlm.nih.gov/pubmed/37663925
http://dx.doi.org/10.1093/crocol/otad020
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author Ananthakrishnan, Ashwin N
Desai, Raj
Lee, Wan-Ju
Griffith, Jenny
Chen, Naijun
Loftus, Edward V
author_facet Ananthakrishnan, Ashwin N
Desai, Raj
Lee, Wan-Ju
Griffith, Jenny
Chen, Naijun
Loftus, Edward V
author_sort Ananthakrishnan, Ashwin N
collection PubMed
description BACKGROUND: This retrospective study gathered medical/pharmacy claims data on patients with inflammatory bowel disease (IBD) between January 01, 2000 and March 31, 2019 from the IBM MarketScan commercial claims database to assess the real-world impact of fatigue on healthcare costs in patients newly diagnosed with IBD. METHODS: Eligible participants were ≥18 years, newly diagnosed with IBD (≥2 separate claims), and had ≥12 months of continuous database enrollment before and after fatigue diagnosis. The date of fatigue diagnosis was the index date; participants were followed for 12 months post-index. Patients with (cases) or without (controls) fatigue were matched 1:1 by propensity score matching. Patients with evidence of prior IBD diagnosis/treatment, or those with a chronic disease other than IBD wherein fatigue is the primary symptom, were excluded. Healthcare resource utilization (HCRU), including hospitalizations, inpatient and outpatient visits, and associated costs were compared between cases and controls. RESULTS: Matched IBD cohorts (21 321 cases/21 321 controls) were identified (42% Crohn’s disease [CD] and 58% ulcerative colitis [UC]) with similar baseline characteristics (average age: 46 years; 60% female). Cases versus controls had significantly more all-cause outpatient visits (incidence rate ratio [IRR], 95% confidence intervals [95% CI]: 1.64 [1.61, 1.67], P < .001) and all-cause hospitalizations (IRR [95% CI]: 1.92 [1.81, 2.04], P < .001); as well as significantly higher all-cause total direct healthcare costs (mean: $24 620 vs. $15 324; P < .001). Similar findings were observed for IBD-related outcomes, as well as in CD- and UC-specific subgroups. CONCLUSIONS: Presence of fatigue is associated with an increase in HCRU and total medical costs among patients newly diagnosed with IBD.
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spelling pubmed-104706652023-09-01 Economic Burden of Fatigue in Inflammatory Bowel Disease Ananthakrishnan, Ashwin N Desai, Raj Lee, Wan-Ju Griffith, Jenny Chen, Naijun Loftus, Edward V Crohns Colitis 360 Observations and Research BACKGROUND: This retrospective study gathered medical/pharmacy claims data on patients with inflammatory bowel disease (IBD) between January 01, 2000 and March 31, 2019 from the IBM MarketScan commercial claims database to assess the real-world impact of fatigue on healthcare costs in patients newly diagnosed with IBD. METHODS: Eligible participants were ≥18 years, newly diagnosed with IBD (≥2 separate claims), and had ≥12 months of continuous database enrollment before and after fatigue diagnosis. The date of fatigue diagnosis was the index date; participants were followed for 12 months post-index. Patients with (cases) or without (controls) fatigue were matched 1:1 by propensity score matching. Patients with evidence of prior IBD diagnosis/treatment, or those with a chronic disease other than IBD wherein fatigue is the primary symptom, were excluded. Healthcare resource utilization (HCRU), including hospitalizations, inpatient and outpatient visits, and associated costs were compared between cases and controls. RESULTS: Matched IBD cohorts (21 321 cases/21 321 controls) were identified (42% Crohn’s disease [CD] and 58% ulcerative colitis [UC]) with similar baseline characteristics (average age: 46 years; 60% female). Cases versus controls had significantly more all-cause outpatient visits (incidence rate ratio [IRR], 95% confidence intervals [95% CI]: 1.64 [1.61, 1.67], P < .001) and all-cause hospitalizations (IRR [95% CI]: 1.92 [1.81, 2.04], P < .001); as well as significantly higher all-cause total direct healthcare costs (mean: $24 620 vs. $15 324; P < .001). Similar findings were observed for IBD-related outcomes, as well as in CD- and UC-specific subgroups. CONCLUSIONS: Presence of fatigue is associated with an increase in HCRU and total medical costs among patients newly diagnosed with IBD. Oxford University Press 2023-04-20 /pmc/articles/PMC10470665/ /pubmed/37663925 http://dx.doi.org/10.1093/crocol/otad020 Text en © The Author(s) 2023. Published by Oxford University Press on behalf of Crohn's & Colitis Foundation. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Observations and Research
Ananthakrishnan, Ashwin N
Desai, Raj
Lee, Wan-Ju
Griffith, Jenny
Chen, Naijun
Loftus, Edward V
Economic Burden of Fatigue in Inflammatory Bowel Disease
title Economic Burden of Fatigue in Inflammatory Bowel Disease
title_full Economic Burden of Fatigue in Inflammatory Bowel Disease
title_fullStr Economic Burden of Fatigue in Inflammatory Bowel Disease
title_full_unstemmed Economic Burden of Fatigue in Inflammatory Bowel Disease
title_short Economic Burden of Fatigue in Inflammatory Bowel Disease
title_sort economic burden of fatigue in inflammatory bowel disease
topic Observations and Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10470665/
https://www.ncbi.nlm.nih.gov/pubmed/37663925
http://dx.doi.org/10.1093/crocol/otad020
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