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Pan-cancer analyses reveal GTSE1 as a biomarker for the immunosuppressive tumor microenvironment

G2 and S phase-expressed-1 (GTSE1) has been reported to be associated with poor prognosis in many cancer types. However, the knowledge of GTSE1 across 33 cancer types remains scarce, and the mechanisms by which GTSE1 promotes cancer development remain incompletely understood. R language and TIMER2.0...

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Autores principales: Tan, Ke, Fang, Zixuan, Kong, Lingzhen, Cheng, Chen, Hwang, Sydney, Xu, Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10470696/
https://www.ncbi.nlm.nih.gov/pubmed/37653815
http://dx.doi.org/10.1097/MD.0000000000034996
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author Tan, Ke
Fang, Zixuan
Kong, Lingzhen
Cheng, Chen
Hwang, Sydney
Xu, Min
author_facet Tan, Ke
Fang, Zixuan
Kong, Lingzhen
Cheng, Chen
Hwang, Sydney
Xu, Min
author_sort Tan, Ke
collection PubMed
description G2 and S phase-expressed-1 (GTSE1) has been reported to be associated with poor prognosis in many cancer types. However, the knowledge of GTSE1 across 33 cancer types remains scarce, and the mechanisms by which GTSE1 promotes cancer development remain incompletely understood. R language and TIMER2.0 were used to analyze the clinical relevance of GTSE1 across > 10,000 subjects representing 33 cancer types based on the cancer genome atlas databases. The expression of GTSE1 was upregulated in almost all cancer types and hyperactivity of GTSE1 is likely to induce DNA repair response and positively correlates with the tumor mutational burden and microsatellite instability which are both promising predictive biomarkers for immunotherapy. GTSE1 was upregulated in TP53 mutation patients. Additionally, GTSE1 also positively correlates with tumor purity and tumor infiltration of immune-suppressive myeloid-derived suppressor cells. Consistently, high expression of GTSE1 is associated with poor patient survival in many cancer types. Conclusion: Our study provides new insights into the diagnostic and prognostic role of GTSE1 in cancers and suggests therapeutic approaches for GTSE1-overexpressing cancers by targeting DNA repair response, and the tumor immune microenvironment.
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spelling pubmed-104706962023-09-01 Pan-cancer analyses reveal GTSE1 as a biomarker for the immunosuppressive tumor microenvironment Tan, Ke Fang, Zixuan Kong, Lingzhen Cheng, Chen Hwang, Sydney Xu, Min Medicine (Baltimore) 5700 G2 and S phase-expressed-1 (GTSE1) has been reported to be associated with poor prognosis in many cancer types. However, the knowledge of GTSE1 across 33 cancer types remains scarce, and the mechanisms by which GTSE1 promotes cancer development remain incompletely understood. R language and TIMER2.0 were used to analyze the clinical relevance of GTSE1 across > 10,000 subjects representing 33 cancer types based on the cancer genome atlas databases. The expression of GTSE1 was upregulated in almost all cancer types and hyperactivity of GTSE1 is likely to induce DNA repair response and positively correlates with the tumor mutational burden and microsatellite instability which are both promising predictive biomarkers for immunotherapy. GTSE1 was upregulated in TP53 mutation patients. Additionally, GTSE1 also positively correlates with tumor purity and tumor infiltration of immune-suppressive myeloid-derived suppressor cells. Consistently, high expression of GTSE1 is associated with poor patient survival in many cancer types. Conclusion: Our study provides new insights into the diagnostic and prognostic role of GTSE1 in cancers and suggests therapeutic approaches for GTSE1-overexpressing cancers by targeting DNA repair response, and the tumor immune microenvironment. Lippincott Williams & Wilkins 2023-08-25 /pmc/articles/PMC10470696/ /pubmed/37653815 http://dx.doi.org/10.1097/MD.0000000000034996 Text en Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC) (https://creativecommons.org/licenses/by-nc/4.0/) , where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal.
spellingShingle 5700
Tan, Ke
Fang, Zixuan
Kong, Lingzhen
Cheng, Chen
Hwang, Sydney
Xu, Min
Pan-cancer analyses reveal GTSE1 as a biomarker for the immunosuppressive tumor microenvironment
title Pan-cancer analyses reveal GTSE1 as a biomarker for the immunosuppressive tumor microenvironment
title_full Pan-cancer analyses reveal GTSE1 as a biomarker for the immunosuppressive tumor microenvironment
title_fullStr Pan-cancer analyses reveal GTSE1 as a biomarker for the immunosuppressive tumor microenvironment
title_full_unstemmed Pan-cancer analyses reveal GTSE1 as a biomarker for the immunosuppressive tumor microenvironment
title_short Pan-cancer analyses reveal GTSE1 as a biomarker for the immunosuppressive tumor microenvironment
title_sort pan-cancer analyses reveal gtse1 as a biomarker for the immunosuppressive tumor microenvironment
topic 5700
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10470696/
https://www.ncbi.nlm.nih.gov/pubmed/37653815
http://dx.doi.org/10.1097/MD.0000000000034996
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