Metabolically distinct roles of NAD synthetase and NAD kinase define the essentiality of NAD and NADP in Mycobacterium tuberculosis

Nicotinamide adenine dinucleotide (NAD) and its phosphorylated derivative (NADP) are essential cofactors that participate in hundreds of biochemical reactions and have emerged as therapeutic targets in cancer, metabolic disorders, neurodegenerative diseases, and infections, including tuberculosis. T...

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Detalles Bibliográficos
Autores principales: Sharma, Ritu, Hartman, Travis E., Beites, Tiago, Kim, Jee-Hyun, Eoh, Hyungjin, Engelhart, Curtis A., Zhu, Linnan, Wilson, Daniel J., Aldrich, Courtney C., Ehrt, Sabine, Rhee, Kyu Young, Schnappinger, Dirk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10470730/
https://www.ncbi.nlm.nih.gov/pubmed/37350592
http://dx.doi.org/10.1128/mbio.00340-23

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