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Investigation of the causal relationship between breast cancer and autoimmune diseases: A bidirectional mendelian randomization study

A clear bidirectional relationship exists between malignant cancers including breast cancer and different autoimmune diseases. However, none of the studies have assessed whether this association is causal and none have used Mendelian randomization for determining this relationship. This study theref...

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Autores principales: Lu, Yuyang, Ma, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10470805/
https://www.ncbi.nlm.nih.gov/pubmed/37653788
http://dx.doi.org/10.1097/MD.0000000000034612
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author Lu, Yuyang
Ma, Li
author_facet Lu, Yuyang
Ma, Li
author_sort Lu, Yuyang
collection PubMed
description A clear bidirectional relationship exists between malignant cancers including breast cancer and different autoimmune diseases. However, none of the studies have assessed whether this association is causal and none have used Mendelian randomization for determining this relationship. This study therefore investigated the causal relationship between autoimmune diseases and breast cancer using the Mendelian randomization approach. Summary statistical data were obtained from genome-wide association studies to investigate the causal relationship between different autoimmune diseases including Graves’ disease, Sjögren’s syndrome, Crohn disease, systemic sclerosis, and psoriasis and breast cancer risk. The results revealed no strong evidence to support the causal relationship between Graves disease (odds ratio [OR] = 0.9958; 95% confidence interval [CI]: 0.9982–1.0035), Sjögren’s syndrome (OR = 1.0018; 95% CI: 0.9950–1.0087), Crohn disease (OR = 2.1195, 95% CI: 0.1872–23.9978), systemic sclerosis (OR = 1.0024; 95% CI: 0.997–1.0079), and psoriasis (OR = 1.0016; 95% CI: 0.9913–1.0121) to breast cancer risk. A similar result was obtained in the reverse Mendelian randomization analysis. Our study provides evidence that autoimmune diseases might not have a causal relationship with breast cancer risk in the European population and concludes that shared genetic effects or environmental confounders.
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spelling pubmed-104708052023-09-01 Investigation of the causal relationship between breast cancer and autoimmune diseases: A bidirectional mendelian randomization study Lu, Yuyang Ma, Li Medicine (Baltimore) Research Article: Observational Study A clear bidirectional relationship exists between malignant cancers including breast cancer and different autoimmune diseases. However, none of the studies have assessed whether this association is causal and none have used Mendelian randomization for determining this relationship. This study therefore investigated the causal relationship between autoimmune diseases and breast cancer using the Mendelian randomization approach. Summary statistical data were obtained from genome-wide association studies to investigate the causal relationship between different autoimmune diseases including Graves’ disease, Sjögren’s syndrome, Crohn disease, systemic sclerosis, and psoriasis and breast cancer risk. The results revealed no strong evidence to support the causal relationship between Graves disease (odds ratio [OR] = 0.9958; 95% confidence interval [CI]: 0.9982–1.0035), Sjögren’s syndrome (OR = 1.0018; 95% CI: 0.9950–1.0087), Crohn disease (OR = 2.1195, 95% CI: 0.1872–23.9978), systemic sclerosis (OR = 1.0024; 95% CI: 0.997–1.0079), and psoriasis (OR = 1.0016; 95% CI: 0.9913–1.0121) to breast cancer risk. A similar result was obtained in the reverse Mendelian randomization analysis. Our study provides evidence that autoimmune diseases might not have a causal relationship with breast cancer risk in the European population and concludes that shared genetic effects or environmental confounders. Lippincott Williams & Wilkins 2023-08-25 /pmc/articles/PMC10470805/ /pubmed/37653788 http://dx.doi.org/10.1097/MD.0000000000034612 Text en Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC) (https://creativecommons.org/licenses/by-nc/4.0/) , where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal.
spellingShingle Research Article: Observational Study
Lu, Yuyang
Ma, Li
Investigation of the causal relationship between breast cancer and autoimmune diseases: A bidirectional mendelian randomization study
title Investigation of the causal relationship between breast cancer and autoimmune diseases: A bidirectional mendelian randomization study
title_full Investigation of the causal relationship between breast cancer and autoimmune diseases: A bidirectional mendelian randomization study
title_fullStr Investigation of the causal relationship between breast cancer and autoimmune diseases: A bidirectional mendelian randomization study
title_full_unstemmed Investigation of the causal relationship between breast cancer and autoimmune diseases: A bidirectional mendelian randomization study
title_short Investigation of the causal relationship between breast cancer and autoimmune diseases: A bidirectional mendelian randomization study
title_sort investigation of the causal relationship between breast cancer and autoimmune diseases: a bidirectional mendelian randomization study
topic Research Article: Observational Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10470805/
https://www.ncbi.nlm.nih.gov/pubmed/37653788
http://dx.doi.org/10.1097/MD.0000000000034612
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