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Health-related Quality of Life Profile of Newly Diagnosed Patients With Myelodysplastic Syndromes by Age, Sex, and Risk Group: A Real-world Study by the GIMEMA
Health-related quality of life (HRQoL) is an important goal of therapy for patients with myelodysplastic syndromes (MDS); however, little is known about HRQoL of these patients at clinical presentation. We report HRQoL profile of newly diagnosed patients with MDS across both the the International Pr...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Lippincott Williams & Wilkins
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10470813/ https://www.ncbi.nlm.nih.gov/pubmed/37663671 http://dx.doi.org/10.1097/HS9.0000000000000944 |
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author | Efficace, Fabio Al Essa, Wael Platzbecker, Uwe Niscola, Pasquale Palumbo, Giuseppe A. Caocci, Giovanni Cottone, Francesco Breccia, Massimo Luppi, Mario Stauder, Reinhard Ricco, Alessandra Petranovic, Duska Baron, Frederic Voso, Maria Teresa Fianchi, Luana Frairia, Chiara Capodanno, Isabella Sarlo, Chiara Fedele, Marilena Lemoli, Roberto Massimo Invernizzi, Rosangela Vallisa, Daniele Di Renzo, Nicola Fozza, Claudio Doro, Maribel Giesinger, Johannes M. Vignetti, Marco |
author_facet | Efficace, Fabio Al Essa, Wael Platzbecker, Uwe Niscola, Pasquale Palumbo, Giuseppe A. Caocci, Giovanni Cottone, Francesco Breccia, Massimo Luppi, Mario Stauder, Reinhard Ricco, Alessandra Petranovic, Duska Baron, Frederic Voso, Maria Teresa Fianchi, Luana Frairia, Chiara Capodanno, Isabella Sarlo, Chiara Fedele, Marilena Lemoli, Roberto Massimo Invernizzi, Rosangela Vallisa, Daniele Di Renzo, Nicola Fozza, Claudio Doro, Maribel Giesinger, Johannes M. Vignetti, Marco |
author_sort | Efficace, Fabio |
collection | PubMed |
description | Health-related quality of life (HRQoL) is an important goal of therapy for patients with myelodysplastic syndromes (MDS); however, little is known about HRQoL of these patients at clinical presentation. We report HRQoL profile of newly diagnosed patients with MDS across both the the International Prognostic Scoring System (IPSS) and IPSS-Revised (IPSS-R) classifications, stratified by sex and age group categories, aiming to also establish European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Core30 (EORTC QLQ-C30) reference values for these patients. Analysis was based on 927 patients with a median age of 73.3 years (interquartile range, 66.0–79.2), of whom 506 and 421 with lower- and higher-risk disease respectively, according to the IPSS classification. HRQoL was assessed with the EORTC QLQ-C30 and substantial differences by age groups and sex, between and within lower- and higher-risk disease categories were observed. For example, within higher-risk disease patients, the youngest group (ie, 30–59 years) tended to report clinically meaningful worse outcomes across various functional and symptom domains compared with older age groups. We also developed 2 regression models allowing for the prediction of EORTC QLQ-C30 reference scores for patients classified according to either the IPSS or the IPSS-R. Investigation of prevalence rates for clinically important problems and symptoms at diagnosis revealed a substantial burden of the disease with >50% of patients reporting clinically important problems with physical functioning and dyspnea in both lower- and higher-risk disease. Our findings may help to enhance the interpretation of HRQoL outcomes in future MDS studies and to better contextualize HRQoL data from routine practice settings. |
format | Online Article Text |
id | pubmed-10470813 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Lippincott Williams & Wilkins |
record_format | MEDLINE/PubMed |
spelling | pubmed-104708132023-09-01 Health-related Quality of Life Profile of Newly Diagnosed Patients With Myelodysplastic Syndromes by Age, Sex, and Risk Group: A Real-world Study by the GIMEMA Efficace, Fabio Al Essa, Wael Platzbecker, Uwe Niscola, Pasquale Palumbo, Giuseppe A. Caocci, Giovanni Cottone, Francesco Breccia, Massimo Luppi, Mario Stauder, Reinhard Ricco, Alessandra Petranovic, Duska Baron, Frederic Voso, Maria Teresa Fianchi, Luana Frairia, Chiara Capodanno, Isabella Sarlo, Chiara Fedele, Marilena Lemoli, Roberto Massimo Invernizzi, Rosangela Vallisa, Daniele Di Renzo, Nicola Fozza, Claudio Doro, Maribel Giesinger, Johannes M. Vignetti, Marco Hemasphere Article Health-related quality of life (HRQoL) is an important goal of therapy for patients with myelodysplastic syndromes (MDS); however, little is known about HRQoL of these patients at clinical presentation. We report HRQoL profile of newly diagnosed patients with MDS across both the the International Prognostic Scoring System (IPSS) and IPSS-Revised (IPSS-R) classifications, stratified by sex and age group categories, aiming to also establish European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Core30 (EORTC QLQ-C30) reference values for these patients. Analysis was based on 927 patients with a median age of 73.3 years (interquartile range, 66.0–79.2), of whom 506 and 421 with lower- and higher-risk disease respectively, according to the IPSS classification. HRQoL was assessed with the EORTC QLQ-C30 and substantial differences by age groups and sex, between and within lower- and higher-risk disease categories were observed. For example, within higher-risk disease patients, the youngest group (ie, 30–59 years) tended to report clinically meaningful worse outcomes across various functional and symptom domains compared with older age groups. We also developed 2 regression models allowing for the prediction of EORTC QLQ-C30 reference scores for patients classified according to either the IPSS or the IPSS-R. Investigation of prevalence rates for clinically important problems and symptoms at diagnosis revealed a substantial burden of the disease with >50% of patients reporting clinically important problems with physical functioning and dyspnea in both lower- and higher-risk disease. Our findings may help to enhance the interpretation of HRQoL outcomes in future MDS studies and to better contextualize HRQoL data from routine practice settings. Lippincott Williams & Wilkins 2023-08-30 /pmc/articles/PMC10470813/ /pubmed/37663671 http://dx.doi.org/10.1097/HS9.0000000000000944 Text en Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the European Hematology Association. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0/) , where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. |
spellingShingle | Article Efficace, Fabio Al Essa, Wael Platzbecker, Uwe Niscola, Pasquale Palumbo, Giuseppe A. Caocci, Giovanni Cottone, Francesco Breccia, Massimo Luppi, Mario Stauder, Reinhard Ricco, Alessandra Petranovic, Duska Baron, Frederic Voso, Maria Teresa Fianchi, Luana Frairia, Chiara Capodanno, Isabella Sarlo, Chiara Fedele, Marilena Lemoli, Roberto Massimo Invernizzi, Rosangela Vallisa, Daniele Di Renzo, Nicola Fozza, Claudio Doro, Maribel Giesinger, Johannes M. Vignetti, Marco Health-related Quality of Life Profile of Newly Diagnosed Patients With Myelodysplastic Syndromes by Age, Sex, and Risk Group: A Real-world Study by the GIMEMA |
title | Health-related Quality of Life Profile of Newly Diagnosed Patients With Myelodysplastic Syndromes by Age, Sex, and Risk Group: A Real-world Study by the GIMEMA |
title_full | Health-related Quality of Life Profile of Newly Diagnosed Patients With Myelodysplastic Syndromes by Age, Sex, and Risk Group: A Real-world Study by the GIMEMA |
title_fullStr | Health-related Quality of Life Profile of Newly Diagnosed Patients With Myelodysplastic Syndromes by Age, Sex, and Risk Group: A Real-world Study by the GIMEMA |
title_full_unstemmed | Health-related Quality of Life Profile of Newly Diagnosed Patients With Myelodysplastic Syndromes by Age, Sex, and Risk Group: A Real-world Study by the GIMEMA |
title_short | Health-related Quality of Life Profile of Newly Diagnosed Patients With Myelodysplastic Syndromes by Age, Sex, and Risk Group: A Real-world Study by the GIMEMA |
title_sort | health-related quality of life profile of newly diagnosed patients with myelodysplastic syndromes by age, sex, and risk group: a real-world study by the gimema |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10470813/ https://www.ncbi.nlm.nih.gov/pubmed/37663671 http://dx.doi.org/10.1097/HS9.0000000000000944 |
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