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Health-related Quality of Life Profile of Newly Diagnosed Patients With Myelodysplastic Syndromes by Age, Sex, and Risk Group: A Real-world Study by the GIMEMA

Health-related quality of life (HRQoL) is an important goal of therapy for patients with myelodysplastic syndromes (MDS); however, little is known about HRQoL of these patients at clinical presentation. We report HRQoL profile of newly diagnosed patients with MDS across both the the International Pr...

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Autores principales: Efficace, Fabio, Al Essa, Wael, Platzbecker, Uwe, Niscola, Pasquale, Palumbo, Giuseppe A., Caocci, Giovanni, Cottone, Francesco, Breccia, Massimo, Luppi, Mario, Stauder, Reinhard, Ricco, Alessandra, Petranovic, Duska, Baron, Frederic, Voso, Maria Teresa, Fianchi, Luana, Frairia, Chiara, Capodanno, Isabella, Sarlo, Chiara, Fedele, Marilena, Lemoli, Roberto Massimo, Invernizzi, Rosangela, Vallisa, Daniele, Di Renzo, Nicola, Fozza, Claudio, Doro, Maribel, Giesinger, Johannes M., Vignetti, Marco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10470813/
https://www.ncbi.nlm.nih.gov/pubmed/37663671
http://dx.doi.org/10.1097/HS9.0000000000000944
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author Efficace, Fabio
Al Essa, Wael
Platzbecker, Uwe
Niscola, Pasquale
Palumbo, Giuseppe A.
Caocci, Giovanni
Cottone, Francesco
Breccia, Massimo
Luppi, Mario
Stauder, Reinhard
Ricco, Alessandra
Petranovic, Duska
Baron, Frederic
Voso, Maria Teresa
Fianchi, Luana
Frairia, Chiara
Capodanno, Isabella
Sarlo, Chiara
Fedele, Marilena
Lemoli, Roberto Massimo
Invernizzi, Rosangela
Vallisa, Daniele
Di Renzo, Nicola
Fozza, Claudio
Doro, Maribel
Giesinger, Johannes M.
Vignetti, Marco
author_facet Efficace, Fabio
Al Essa, Wael
Platzbecker, Uwe
Niscola, Pasquale
Palumbo, Giuseppe A.
Caocci, Giovanni
Cottone, Francesco
Breccia, Massimo
Luppi, Mario
Stauder, Reinhard
Ricco, Alessandra
Petranovic, Duska
Baron, Frederic
Voso, Maria Teresa
Fianchi, Luana
Frairia, Chiara
Capodanno, Isabella
Sarlo, Chiara
Fedele, Marilena
Lemoli, Roberto Massimo
Invernizzi, Rosangela
Vallisa, Daniele
Di Renzo, Nicola
Fozza, Claudio
Doro, Maribel
Giesinger, Johannes M.
Vignetti, Marco
author_sort Efficace, Fabio
collection PubMed
description Health-related quality of life (HRQoL) is an important goal of therapy for patients with myelodysplastic syndromes (MDS); however, little is known about HRQoL of these patients at clinical presentation. We report HRQoL profile of newly diagnosed patients with MDS across both the the International Prognostic Scoring System (IPSS) and IPSS-Revised (IPSS-R) classifications, stratified by sex and age group categories, aiming to also establish European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Core30 (EORTC QLQ-C30) reference values for these patients. Analysis was based on 927 patients with a median age of 73.3 years (interquartile range, 66.0–79.2), of whom 506 and 421 with lower- and higher-risk disease respectively, according to the IPSS classification. HRQoL was assessed with the EORTC QLQ-C30 and substantial differences by age groups and sex, between and within lower- and higher-risk disease categories were observed. For example, within higher-risk disease patients, the youngest group (ie, 30–59 years) tended to report clinically meaningful worse outcomes across various functional and symptom domains compared with older age groups. We also developed 2 regression models allowing for the prediction of EORTC QLQ-C30 reference scores for patients classified according to either the IPSS or the IPSS-R. Investigation of prevalence rates for clinically important problems and symptoms at diagnosis revealed a substantial burden of the disease with >50% of patients reporting clinically important problems with physical functioning and dyspnea in both lower- and higher-risk disease. Our findings may help to enhance the interpretation of HRQoL outcomes in future MDS studies and to better contextualize HRQoL data from routine practice settings.
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spelling pubmed-104708132023-09-01 Health-related Quality of Life Profile of Newly Diagnosed Patients With Myelodysplastic Syndromes by Age, Sex, and Risk Group: A Real-world Study by the GIMEMA Efficace, Fabio Al Essa, Wael Platzbecker, Uwe Niscola, Pasquale Palumbo, Giuseppe A. Caocci, Giovanni Cottone, Francesco Breccia, Massimo Luppi, Mario Stauder, Reinhard Ricco, Alessandra Petranovic, Duska Baron, Frederic Voso, Maria Teresa Fianchi, Luana Frairia, Chiara Capodanno, Isabella Sarlo, Chiara Fedele, Marilena Lemoli, Roberto Massimo Invernizzi, Rosangela Vallisa, Daniele Di Renzo, Nicola Fozza, Claudio Doro, Maribel Giesinger, Johannes M. Vignetti, Marco Hemasphere Article Health-related quality of life (HRQoL) is an important goal of therapy for patients with myelodysplastic syndromes (MDS); however, little is known about HRQoL of these patients at clinical presentation. We report HRQoL profile of newly diagnosed patients with MDS across both the the International Prognostic Scoring System (IPSS) and IPSS-Revised (IPSS-R) classifications, stratified by sex and age group categories, aiming to also establish European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Core30 (EORTC QLQ-C30) reference values for these patients. Analysis was based on 927 patients with a median age of 73.3 years (interquartile range, 66.0–79.2), of whom 506 and 421 with lower- and higher-risk disease respectively, according to the IPSS classification. HRQoL was assessed with the EORTC QLQ-C30 and substantial differences by age groups and sex, between and within lower- and higher-risk disease categories were observed. For example, within higher-risk disease patients, the youngest group (ie, 30–59 years) tended to report clinically meaningful worse outcomes across various functional and symptom domains compared with older age groups. We also developed 2 regression models allowing for the prediction of EORTC QLQ-C30 reference scores for patients classified according to either the IPSS or the IPSS-R. Investigation of prevalence rates for clinically important problems and symptoms at diagnosis revealed a substantial burden of the disease with >50% of patients reporting clinically important problems with physical functioning and dyspnea in both lower- and higher-risk disease. Our findings may help to enhance the interpretation of HRQoL outcomes in future MDS studies and to better contextualize HRQoL data from routine practice settings. Lippincott Williams & Wilkins 2023-08-30 /pmc/articles/PMC10470813/ /pubmed/37663671 http://dx.doi.org/10.1097/HS9.0000000000000944 Text en Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the European Hematology Association. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0/) , where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
spellingShingle Article
Efficace, Fabio
Al Essa, Wael
Platzbecker, Uwe
Niscola, Pasquale
Palumbo, Giuseppe A.
Caocci, Giovanni
Cottone, Francesco
Breccia, Massimo
Luppi, Mario
Stauder, Reinhard
Ricco, Alessandra
Petranovic, Duska
Baron, Frederic
Voso, Maria Teresa
Fianchi, Luana
Frairia, Chiara
Capodanno, Isabella
Sarlo, Chiara
Fedele, Marilena
Lemoli, Roberto Massimo
Invernizzi, Rosangela
Vallisa, Daniele
Di Renzo, Nicola
Fozza, Claudio
Doro, Maribel
Giesinger, Johannes M.
Vignetti, Marco
Health-related Quality of Life Profile of Newly Diagnosed Patients With Myelodysplastic Syndromes by Age, Sex, and Risk Group: A Real-world Study by the GIMEMA
title Health-related Quality of Life Profile of Newly Diagnosed Patients With Myelodysplastic Syndromes by Age, Sex, and Risk Group: A Real-world Study by the GIMEMA
title_full Health-related Quality of Life Profile of Newly Diagnosed Patients With Myelodysplastic Syndromes by Age, Sex, and Risk Group: A Real-world Study by the GIMEMA
title_fullStr Health-related Quality of Life Profile of Newly Diagnosed Patients With Myelodysplastic Syndromes by Age, Sex, and Risk Group: A Real-world Study by the GIMEMA
title_full_unstemmed Health-related Quality of Life Profile of Newly Diagnosed Patients With Myelodysplastic Syndromes by Age, Sex, and Risk Group: A Real-world Study by the GIMEMA
title_short Health-related Quality of Life Profile of Newly Diagnosed Patients With Myelodysplastic Syndromes by Age, Sex, and Risk Group: A Real-world Study by the GIMEMA
title_sort health-related quality of life profile of newly diagnosed patients with myelodysplastic syndromes by age, sex, and risk group: a real-world study by the gimema
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10470813/
https://www.ncbi.nlm.nih.gov/pubmed/37663671
http://dx.doi.org/10.1097/HS9.0000000000000944
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