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Real-world survival outcomes of wedge resection versus lobectomy for cT1a/b cN0 cM0 non-small cell lung cancer: a single center retrospective analysis

BACKGROUND: JCOG0802/WJOG4607L showed benefits in overall survival (OS) of segmentectomy. CALGB 140503 confirmed that sublobar resection was not inferior to lobectomy concerning recurrence-free survival (RFS) but did not provide specific OS and RFS according to the techniques of sublobar resections....

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Autores principales: Bertolaccini, Luca, Cara, Andrea, Chiari, Matteo, Diotti, Cristina, Glick, Nimrod, Mohamed, Shehab, Uslenghi, Clarissa, Mazzella, Antonio, Brambilla, Daniela, Bertolotti, Raffaella, Sedda, Giulia, Spaggiari, Lorenzo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10470827/
https://www.ncbi.nlm.nih.gov/pubmed/37664070
http://dx.doi.org/10.3389/fonc.2023.1226429
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author Bertolaccini, Luca
Cara, Andrea
Chiari, Matteo
Diotti, Cristina
Glick, Nimrod
Mohamed, Shehab
Uslenghi, Clarissa
Mazzella, Antonio
Brambilla, Daniela
Bertolotti, Raffaella
Sedda, Giulia
Spaggiari, Lorenzo
author_facet Bertolaccini, Luca
Cara, Andrea
Chiari, Matteo
Diotti, Cristina
Glick, Nimrod
Mohamed, Shehab
Uslenghi, Clarissa
Mazzella, Antonio
Brambilla, Daniela
Bertolotti, Raffaella
Sedda, Giulia
Spaggiari, Lorenzo
author_sort Bertolaccini, Luca
collection PubMed
description BACKGROUND: JCOG0802/WJOG4607L showed benefits in overall survival (OS) of segmentectomy. CALGB 140503 confirmed that sublobar resection was not inferior to lobectomy concerning recurrence-free survival (RFS) but did not provide specific OS and RFS according to the techniques of sublobar resections. Hence, we retrospectively analyze the survival differences between wedge resection and lobectomies for stage IA lung cancer. METHODS: We reviewed the clinical records of patients with clinical stage IA NSCLC over 20 years. The inclusion criteria were: preoperative staging with CT scan and whole body CT/PET; tumor size <20 mm; wedge resections or lobectomies with or without lymph node dissection; NSCLC as the only primary tumor during the follow-up period. We excluded: multiple invasive lung cancer; positive resection margin; preoperative evidence of nodal disease; distant metastasis at presentation; follow-up time <5 years. The reverse Kaplan – Meier method estimated the median OS and PFS and compared them by the log-rank test. The stratified backward stepwise Cox regression model was employed for multivariable survival analyses. RESULTS: 539 patients were identified: 476 (88.3%) lobectomies and 63 (11.7%) wedge resections. The median OS time for the whole cohort was 189.7 months (range: 173.7 – 213.9 months). The 5-year wedge resection and lobectomy OS were 82.2% and 87.0%. The 5-year RFS of wedge resection and lobectomy were 17.8% and 28.9%. The log-rank test showed no significant differences (p = 0.39) between wedge resections and lobectomies regarding OS and RFS (p = 0.23). CONCLUSIONS: Lobectomy and wedge resection are equivalent oncologic treatments for individuals with cN0/cM0 stage IA NSCLC <20 mm. Validating the current findings requires a prospective, randomized comparison between wedge resection and standard lobectomy to establish the prognostic significance of wedge resection.
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spelling pubmed-104708272023-09-01 Real-world survival outcomes of wedge resection versus lobectomy for cT1a/b cN0 cM0 non-small cell lung cancer: a single center retrospective analysis Bertolaccini, Luca Cara, Andrea Chiari, Matteo Diotti, Cristina Glick, Nimrod Mohamed, Shehab Uslenghi, Clarissa Mazzella, Antonio Brambilla, Daniela Bertolotti, Raffaella Sedda, Giulia Spaggiari, Lorenzo Front Oncol Oncology BACKGROUND: JCOG0802/WJOG4607L showed benefits in overall survival (OS) of segmentectomy. CALGB 140503 confirmed that sublobar resection was not inferior to lobectomy concerning recurrence-free survival (RFS) but did not provide specific OS and RFS according to the techniques of sublobar resections. Hence, we retrospectively analyze the survival differences between wedge resection and lobectomies for stage IA lung cancer. METHODS: We reviewed the clinical records of patients with clinical stage IA NSCLC over 20 years. The inclusion criteria were: preoperative staging with CT scan and whole body CT/PET; tumor size <20 mm; wedge resections or lobectomies with or without lymph node dissection; NSCLC as the only primary tumor during the follow-up period. We excluded: multiple invasive lung cancer; positive resection margin; preoperative evidence of nodal disease; distant metastasis at presentation; follow-up time <5 years. The reverse Kaplan – Meier method estimated the median OS and PFS and compared them by the log-rank test. The stratified backward stepwise Cox regression model was employed for multivariable survival analyses. RESULTS: 539 patients were identified: 476 (88.3%) lobectomies and 63 (11.7%) wedge resections. The median OS time for the whole cohort was 189.7 months (range: 173.7 – 213.9 months). The 5-year wedge resection and lobectomy OS were 82.2% and 87.0%. The 5-year RFS of wedge resection and lobectomy were 17.8% and 28.9%. The log-rank test showed no significant differences (p = 0.39) between wedge resections and lobectomies regarding OS and RFS (p = 0.23). CONCLUSIONS: Lobectomy and wedge resection are equivalent oncologic treatments for individuals with cN0/cM0 stage IA NSCLC <20 mm. Validating the current findings requires a prospective, randomized comparison between wedge resection and standard lobectomy to establish the prognostic significance of wedge resection. Frontiers Media S.A. 2023-08-17 /pmc/articles/PMC10470827/ /pubmed/37664070 http://dx.doi.org/10.3389/fonc.2023.1226429 Text en Copyright © 2023 Bertolaccini, Cara, Chiari, Diotti, Glick, Mohamed, Uslenghi, Mazzella, Brambilla, Bertolotti, Sedda and Spaggiari https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Bertolaccini, Luca
Cara, Andrea
Chiari, Matteo
Diotti, Cristina
Glick, Nimrod
Mohamed, Shehab
Uslenghi, Clarissa
Mazzella, Antonio
Brambilla, Daniela
Bertolotti, Raffaella
Sedda, Giulia
Spaggiari, Lorenzo
Real-world survival outcomes of wedge resection versus lobectomy for cT1a/b cN0 cM0 non-small cell lung cancer: a single center retrospective analysis
title Real-world survival outcomes of wedge resection versus lobectomy for cT1a/b cN0 cM0 non-small cell lung cancer: a single center retrospective analysis
title_full Real-world survival outcomes of wedge resection versus lobectomy for cT1a/b cN0 cM0 non-small cell lung cancer: a single center retrospective analysis
title_fullStr Real-world survival outcomes of wedge resection versus lobectomy for cT1a/b cN0 cM0 non-small cell lung cancer: a single center retrospective analysis
title_full_unstemmed Real-world survival outcomes of wedge resection versus lobectomy for cT1a/b cN0 cM0 non-small cell lung cancer: a single center retrospective analysis
title_short Real-world survival outcomes of wedge resection versus lobectomy for cT1a/b cN0 cM0 non-small cell lung cancer: a single center retrospective analysis
title_sort real-world survival outcomes of wedge resection versus lobectomy for ct1a/b cn0 cm0 non-small cell lung cancer: a single center retrospective analysis
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10470827/
https://www.ncbi.nlm.nih.gov/pubmed/37664070
http://dx.doi.org/10.3389/fonc.2023.1226429
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