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Azole potentiation in Candida species
Fungal infections are rising, with over 1.5 billion cases and more than 1 million deaths recorded each year. Among these, Candida infections are frequent in at-risk populations and the rapid development of drug resistance and tolerance contributes to their clinical persistence. Few antifungal drugs...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10470869/ https://www.ncbi.nlm.nih.gov/pubmed/37651385 http://dx.doi.org/10.1371/journal.ppat.1011583 |
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author | Stenkiewicz-Witeska, Jan S. Ene, Iuliana V. |
author_facet | Stenkiewicz-Witeska, Jan S. Ene, Iuliana V. |
author_sort | Stenkiewicz-Witeska, Jan S. |
collection | PubMed |
description | Fungal infections are rising, with over 1.5 billion cases and more than 1 million deaths recorded each year. Among these, Candida infections are frequent in at-risk populations and the rapid development of drug resistance and tolerance contributes to their clinical persistence. Few antifungal drugs are available, and their efficacy is declining due to the environmental overuse and the expansion of multidrug-resistant species. One way to prolong their utility is by applying them in combination therapy. Here, we highlight recently described azole potentiators belonging to different categories: natural, repurposed, or novel compounds. We showcase examples of molecules and discuss their identified or proposed mode of action. We also emphasise the challenges in azole potentiator development, compounded by the lack of animal testing, the overreliance on Candida albicans and Candida auris, as well as the limited understanding of compound efficacy. |
format | Online Article Text |
id | pubmed-10470869 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-104708692023-09-01 Azole potentiation in Candida species Stenkiewicz-Witeska, Jan S. Ene, Iuliana V. PLoS Pathog Pearls Fungal infections are rising, with over 1.5 billion cases and more than 1 million deaths recorded each year. Among these, Candida infections are frequent in at-risk populations and the rapid development of drug resistance and tolerance contributes to their clinical persistence. Few antifungal drugs are available, and their efficacy is declining due to the environmental overuse and the expansion of multidrug-resistant species. One way to prolong their utility is by applying them in combination therapy. Here, we highlight recently described azole potentiators belonging to different categories: natural, repurposed, or novel compounds. We showcase examples of molecules and discuss their identified or proposed mode of action. We also emphasise the challenges in azole potentiator development, compounded by the lack of animal testing, the overreliance on Candida albicans and Candida auris, as well as the limited understanding of compound efficacy. Public Library of Science 2023-08-31 /pmc/articles/PMC10470869/ /pubmed/37651385 http://dx.doi.org/10.1371/journal.ppat.1011583 Text en © 2023 Stenkiewicz-Witeska, Ene https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Pearls Stenkiewicz-Witeska, Jan S. Ene, Iuliana V. Azole potentiation in Candida species |
title | Azole potentiation in Candida species |
title_full | Azole potentiation in Candida species |
title_fullStr | Azole potentiation in Candida species |
title_full_unstemmed | Azole potentiation in Candida species |
title_short | Azole potentiation in Candida species |
title_sort | azole potentiation in candida species |
topic | Pearls |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10470869/ https://www.ncbi.nlm.nih.gov/pubmed/37651385 http://dx.doi.org/10.1371/journal.ppat.1011583 |
work_keys_str_mv | AT stenkiewiczwiteskajans azolepotentiationincandidaspecies AT eneiulianav azolepotentiationincandidaspecies |