Cargando…

Development of stimuli responsive polymeric nanomedicines modulating tumor microenvironment for improved cancer therapy

The complexity of the tumor microenvironment (TME) severely hinders the therapeutic effects of various cancer treatment modalities. The TME differs from normal tissues owing to the presence of hypoxia, low pH, and immune-suppressive characteristics. Modulation of the TME to reverse tumor growth equi...

Descripción completa

Detalles Bibliográficos
Autores principales: Su, Yuanzhen, Jin, Guanyu, Zhou, Huicong, Yang, Zhaofan, Wang, Lanqing, Mei, Zi, Jin, Qionghua, Lv, Shixian, Chen, Xuesi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: De Gruyter 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10471091/
https://www.ncbi.nlm.nih.gov/pubmed/37724108
http://dx.doi.org/10.1515/mr-2022-0048
_version_ 1785099804789964800
author Su, Yuanzhen
Jin, Guanyu
Zhou, Huicong
Yang, Zhaofan
Wang, Lanqing
Mei, Zi
Jin, Qionghua
Lv, Shixian
Chen, Xuesi
author_facet Su, Yuanzhen
Jin, Guanyu
Zhou, Huicong
Yang, Zhaofan
Wang, Lanqing
Mei, Zi
Jin, Qionghua
Lv, Shixian
Chen, Xuesi
author_sort Su, Yuanzhen
collection PubMed
description The complexity of the tumor microenvironment (TME) severely hinders the therapeutic effects of various cancer treatment modalities. The TME differs from normal tissues owing to the presence of hypoxia, low pH, and immune-suppressive characteristics. Modulation of the TME to reverse tumor growth equilibrium is considered an effective way to treat tumors. Recently, polymeric nanomedicines have been widely used in cancer therapy, because their synthesis can be controlled and they are highly modifiable, and have demonstrated great potential to remodel the TME. In this review, we outline the application of various stimuli responsive polymeric nanomedicines to modulate the TME, aiming to provide insights for the design of the next generation of polymeric nanomedicines and promote the development of polymeric nanomedicines for cancer therapy.
format Online
Article
Text
id pubmed-10471091
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher De Gruyter
record_format MEDLINE/PubMed
spelling pubmed-104710912023-09-18 Development of stimuli responsive polymeric nanomedicines modulating tumor microenvironment for improved cancer therapy Su, Yuanzhen Jin, Guanyu Zhou, Huicong Yang, Zhaofan Wang, Lanqing Mei, Zi Jin, Qionghua Lv, Shixian Chen, Xuesi Med Rev (Berl) Review The complexity of the tumor microenvironment (TME) severely hinders the therapeutic effects of various cancer treatment modalities. The TME differs from normal tissues owing to the presence of hypoxia, low pH, and immune-suppressive characteristics. Modulation of the TME to reverse tumor growth equilibrium is considered an effective way to treat tumors. Recently, polymeric nanomedicines have been widely used in cancer therapy, because their synthesis can be controlled and they are highly modifiable, and have demonstrated great potential to remodel the TME. In this review, we outline the application of various stimuli responsive polymeric nanomedicines to modulate the TME, aiming to provide insights for the design of the next generation of polymeric nanomedicines and promote the development of polymeric nanomedicines for cancer therapy. De Gruyter 2023-03-17 /pmc/articles/PMC10471091/ /pubmed/37724108 http://dx.doi.org/10.1515/mr-2022-0048 Text en © 2023 the author(s), published by De Gruyter, Berlin/Boston https://creativecommons.org/licenses/by-nc-nd/4.0/This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
spellingShingle Review
Su, Yuanzhen
Jin, Guanyu
Zhou, Huicong
Yang, Zhaofan
Wang, Lanqing
Mei, Zi
Jin, Qionghua
Lv, Shixian
Chen, Xuesi
Development of stimuli responsive polymeric nanomedicines modulating tumor microenvironment for improved cancer therapy
title Development of stimuli responsive polymeric nanomedicines modulating tumor microenvironment for improved cancer therapy
title_full Development of stimuli responsive polymeric nanomedicines modulating tumor microenvironment for improved cancer therapy
title_fullStr Development of stimuli responsive polymeric nanomedicines modulating tumor microenvironment for improved cancer therapy
title_full_unstemmed Development of stimuli responsive polymeric nanomedicines modulating tumor microenvironment for improved cancer therapy
title_short Development of stimuli responsive polymeric nanomedicines modulating tumor microenvironment for improved cancer therapy
title_sort development of stimuli responsive polymeric nanomedicines modulating tumor microenvironment for improved cancer therapy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10471091/
https://www.ncbi.nlm.nih.gov/pubmed/37724108
http://dx.doi.org/10.1515/mr-2022-0048
work_keys_str_mv AT suyuanzhen developmentofstimuliresponsivepolymericnanomedicinesmodulatingtumormicroenvironmentforimprovedcancertherapy
AT jinguanyu developmentofstimuliresponsivepolymericnanomedicinesmodulatingtumormicroenvironmentforimprovedcancertherapy
AT zhouhuicong developmentofstimuliresponsivepolymericnanomedicinesmodulatingtumormicroenvironmentforimprovedcancertherapy
AT yangzhaofan developmentofstimuliresponsivepolymericnanomedicinesmodulatingtumormicroenvironmentforimprovedcancertherapy
AT wanglanqing developmentofstimuliresponsivepolymericnanomedicinesmodulatingtumormicroenvironmentforimprovedcancertherapy
AT meizi developmentofstimuliresponsivepolymericnanomedicinesmodulatingtumormicroenvironmentforimprovedcancertherapy
AT jinqionghua developmentofstimuliresponsivepolymericnanomedicinesmodulatingtumormicroenvironmentforimprovedcancertherapy
AT lvshixian developmentofstimuliresponsivepolymericnanomedicinesmodulatingtumormicroenvironmentforimprovedcancertherapy
AT chenxuesi developmentofstimuliresponsivepolymericnanomedicinesmodulatingtumormicroenvironmentforimprovedcancertherapy