Tumorigenesis from non-alcoholic steatohepatitis to hepatocellular carcinoma

Non-alcoholic steatohepatitis (NASH) with metabolic syndrome is increasing to be a main cause of hepatocellular carcinoma (HCC). However, the mechanism of tumorigenesis in NASH induced HCC is still not clear. In this perspective, we will discuss the recent progress that has been made to understand t...

Descripción completa

Detalles Bibliográficos
Autores principales: Yu, Junjie, Pajvani, Utpal B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: De Gruyter 2023
Materias:
Perspective
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10471092/
https://www.ncbi.nlm.nih.gov/pubmed/37724256
http://dx.doi.org/10.1515/mr-2022-0043
_version_ 1785099805044768768
author Yu, Junjie
Pajvani, Utpal B.
author_facet Yu, Junjie
Pajvani, Utpal B.
author_sort Yu, Junjie
collection PubMed
description Non-alcoholic steatohepatitis (NASH) with metabolic syndrome is increasing to be a main cause of hepatocellular carcinoma (HCC). However, the mechanism of tumorigenesis in NASH induced HCC is still not clear. In this perspective, we will discuss the recent progress that has been made to understand the genetic change and the immune microenvironment of HCC, and the remaining questions. Based on the current study, NASH-HCC is likely to have novel mechanism, which needs more investigation in future.
format Online
Article
Text
id pubmed-10471092
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher De Gruyter
record_format MEDLINE/PubMed
spelling pubmed-104710922023-09-18 Tumorigenesis from non-alcoholic steatohepatitis to hepatocellular carcinoma Yu, Junjie Pajvani, Utpal B. Med Rev (Berl) Perspective Non-alcoholic steatohepatitis (NASH) with metabolic syndrome is increasing to be a main cause of hepatocellular carcinoma (HCC). However, the mechanism of tumorigenesis in NASH induced HCC is still not clear. In this perspective, we will discuss the recent progress that has been made to understand the genetic change and the immune microenvironment of HCC, and the remaining questions. Based on the current study, NASH-HCC is likely to have novel mechanism, which needs more investigation in future. De Gruyter 2023-01-06 /pmc/articles/PMC10471092/ /pubmed/37724256 http://dx.doi.org/10.1515/mr-2022-0043 Text en © 2022 the author(s), published by De Gruyter, Berlin/Boston https://creativecommons.org/licenses/by-nc-nd/4.0/This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
spellingShingle Perspective
Yu, Junjie
Pajvani, Utpal B.
Tumorigenesis from non-alcoholic steatohepatitis to hepatocellular carcinoma
title Tumorigenesis from non-alcoholic steatohepatitis to hepatocellular carcinoma
title_full Tumorigenesis from non-alcoholic steatohepatitis to hepatocellular carcinoma
title_fullStr Tumorigenesis from non-alcoholic steatohepatitis to hepatocellular carcinoma
title_full_unstemmed Tumorigenesis from non-alcoholic steatohepatitis to hepatocellular carcinoma
title_short Tumorigenesis from non-alcoholic steatohepatitis to hepatocellular carcinoma
title_sort tumorigenesis from non-alcoholic steatohepatitis to hepatocellular carcinoma
topic Perspective
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10471092/
https://www.ncbi.nlm.nih.gov/pubmed/37724256
http://dx.doi.org/10.1515/mr-2022-0043
work_keys_str_mv AT yujunjie tumorigenesisfromnonalcoholicsteatohepatitistohepatocellularcarcinoma
AT pajvaniutpalb tumorigenesisfromnonalcoholicsteatohepatitistohepatocellularcarcinoma

Ejemplares similares