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Ferritin-based nanomedicine for disease treatment
Ferritin is an endogenous protein which is self-assembled by 24 subunits into a highly uniform nanocage structure. Due to the drug-encapsulating ability in the hollow inner cavity and abundant modification sites on the outer surface, ferritin nanocage has been demonstrated great potential to become...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
De Gruyter
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10471093/ https://www.ncbi.nlm.nih.gov/pubmed/37724111 http://dx.doi.org/10.1515/mr-2023-0001 |
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author | Zhu, Yuanjun Zhu, Yuefeng Cao, Tianmiao Liu, Xiaoyu Liu, Xiaoyan Yan, Yi Shi, Yujie Wang, Jian-Cheng |
author_facet | Zhu, Yuanjun Zhu, Yuefeng Cao, Tianmiao Liu, Xiaoyu Liu, Xiaoyan Yan, Yi Shi, Yujie Wang, Jian-Cheng |
author_sort | Zhu, Yuanjun |
collection | PubMed |
description | Ferritin is an endogenous protein which is self-assembled by 24 subunits into a highly uniform nanocage structure. Due to the drug-encapsulating ability in the hollow inner cavity and abundant modification sites on the outer surface, ferritin nanocage has been demonstrated great potential to become a multi-functional nanomedicine platform. Its good biocompatibility, low toxicity and immunogenicity, intrinsic tumor-targeting ability, high stability, low cost and massive production, together make ferritin nanocage stand out from other nanocarriers. In this review, we summarized ferritin-based nanomedicine in field of disease diagnosis, treatment and prevention. The different types of drugs to be loaded in ferritin, as well as drug-loading methods were classified. The strategies for site-specific and non-specific functional modification of ferritin were investigated, then the application of ferritin for disease imaging, drug delivery and vaccine development were discussed. Finally, the challenges restricting the clinical translation of ferritin-based nanomedicines were analyzed. |
format | Online Article Text |
id | pubmed-10471093 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | De Gruyter |
record_format | MEDLINE/PubMed |
spelling | pubmed-104710932023-09-18 Ferritin-based nanomedicine for disease treatment Zhu, Yuanjun Zhu, Yuefeng Cao, Tianmiao Liu, Xiaoyu Liu, Xiaoyan Yan, Yi Shi, Yujie Wang, Jian-Cheng Med Rev (Berl) Review Ferritin is an endogenous protein which is self-assembled by 24 subunits into a highly uniform nanocage structure. Due to the drug-encapsulating ability in the hollow inner cavity and abundant modification sites on the outer surface, ferritin nanocage has been demonstrated great potential to become a multi-functional nanomedicine platform. Its good biocompatibility, low toxicity and immunogenicity, intrinsic tumor-targeting ability, high stability, low cost and massive production, together make ferritin nanocage stand out from other nanocarriers. In this review, we summarized ferritin-based nanomedicine in field of disease diagnosis, treatment and prevention. The different types of drugs to be loaded in ferritin, as well as drug-loading methods were classified. The strategies for site-specific and non-specific functional modification of ferritin were investigated, then the application of ferritin for disease imaging, drug delivery and vaccine development were discussed. Finally, the challenges restricting the clinical translation of ferritin-based nanomedicines were analyzed. De Gruyter 2023-03-10 /pmc/articles/PMC10471093/ /pubmed/37724111 http://dx.doi.org/10.1515/mr-2023-0001 Text en © 2023 the author(s), published by De Gruyter, Berlin/Boston https://creativecommons.org/licenses/by-nc-nd/4.0/This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. |
spellingShingle | Review Zhu, Yuanjun Zhu, Yuefeng Cao, Tianmiao Liu, Xiaoyu Liu, Xiaoyan Yan, Yi Shi, Yujie Wang, Jian-Cheng Ferritin-based nanomedicine for disease treatment |
title | Ferritin-based nanomedicine for disease treatment |
title_full | Ferritin-based nanomedicine for disease treatment |
title_fullStr | Ferritin-based nanomedicine for disease treatment |
title_full_unstemmed | Ferritin-based nanomedicine for disease treatment |
title_short | Ferritin-based nanomedicine for disease treatment |
title_sort | ferritin-based nanomedicine for disease treatment |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10471093/ https://www.ncbi.nlm.nih.gov/pubmed/37724111 http://dx.doi.org/10.1515/mr-2023-0001 |
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