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G protein–coupled estrogen receptor: a promising therapeutic target for aldosterone-induced hypertension

Aldosterone is one of the most essential hormones synthesized by the adrenal gland because it regulates water and electrolyte balance. G protein–coupled estrogen receptor (GPER) is a newly discovered aldosterone receptor, which is proposed to mediate the non-genomic pathways of aldosterone while the...

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Autores principales: Li, Xuehan, Kuang, Wenlong, Qiu, Zhihua, Zhou, Zihua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10471144/
https://www.ncbi.nlm.nih.gov/pubmed/37664844
http://dx.doi.org/10.3389/fendo.2023.1226458
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author Li, Xuehan
Kuang, Wenlong
Qiu, Zhihua
Zhou, Zihua
author_facet Li, Xuehan
Kuang, Wenlong
Qiu, Zhihua
Zhou, Zihua
author_sort Li, Xuehan
collection PubMed
description Aldosterone is one of the most essential hormones synthesized by the adrenal gland because it regulates water and electrolyte balance. G protein–coupled estrogen receptor (GPER) is a newly discovered aldosterone receptor, which is proposed to mediate the non-genomic pathways of aldosterone while the hormone simultaneously interacts with mineralocorticoid receptor. In contrast to its cardio-protective role in postmenopausal women via its interaction with estrogen, GPER seems to trigger vasoconstriction effects and can further induce water and sodium retention in the presence of aldosterone, indicating two entirely different binding sites and effects for estrogen and aldosterone. Accumulating evidence also points to a role of aldosterone in mediating hypertension and its risk factors via the interaction with GPER. Therefore, with this review, we aimed to summarize the research on these interactions to help (1) elucidate the role of GPER activated by aldosterone in the blood vessels, heart, and kidney; (2) compare the non-genomic actions between aldosterone and estrogen mediated by GPER; and (3) address the potential of GPER as a new promising therapeutic target for aldosterone-induced hypertension.
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spelling pubmed-104711442023-09-01 G protein–coupled estrogen receptor: a promising therapeutic target for aldosterone-induced hypertension Li, Xuehan Kuang, Wenlong Qiu, Zhihua Zhou, Zihua Front Endocrinol (Lausanne) Endocrinology Aldosterone is one of the most essential hormones synthesized by the adrenal gland because it regulates water and electrolyte balance. G protein–coupled estrogen receptor (GPER) is a newly discovered aldosterone receptor, which is proposed to mediate the non-genomic pathways of aldosterone while the hormone simultaneously interacts with mineralocorticoid receptor. In contrast to its cardio-protective role in postmenopausal women via its interaction with estrogen, GPER seems to trigger vasoconstriction effects and can further induce water and sodium retention in the presence of aldosterone, indicating two entirely different binding sites and effects for estrogen and aldosterone. Accumulating evidence also points to a role of aldosterone in mediating hypertension and its risk factors via the interaction with GPER. Therefore, with this review, we aimed to summarize the research on these interactions to help (1) elucidate the role of GPER activated by aldosterone in the blood vessels, heart, and kidney; (2) compare the non-genomic actions between aldosterone and estrogen mediated by GPER; and (3) address the potential of GPER as a new promising therapeutic target for aldosterone-induced hypertension. Frontiers Media S.A. 2023-08-17 /pmc/articles/PMC10471144/ /pubmed/37664844 http://dx.doi.org/10.3389/fendo.2023.1226458 Text en Copyright © 2023 Li, Kuang, Qiu and Zhou https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Li, Xuehan
Kuang, Wenlong
Qiu, Zhihua
Zhou, Zihua
G protein–coupled estrogen receptor: a promising therapeutic target for aldosterone-induced hypertension
title G protein–coupled estrogen receptor: a promising therapeutic target for aldosterone-induced hypertension
title_full G protein–coupled estrogen receptor: a promising therapeutic target for aldosterone-induced hypertension
title_fullStr G protein–coupled estrogen receptor: a promising therapeutic target for aldosterone-induced hypertension
title_full_unstemmed G protein–coupled estrogen receptor: a promising therapeutic target for aldosterone-induced hypertension
title_short G protein–coupled estrogen receptor: a promising therapeutic target for aldosterone-induced hypertension
title_sort g protein–coupled estrogen receptor: a promising therapeutic target for aldosterone-induced hypertension
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10471144/
https://www.ncbi.nlm.nih.gov/pubmed/37664844
http://dx.doi.org/10.3389/fendo.2023.1226458
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