Hypoxic erythrocytes mediate cardioprotection through activation of soluble guanylate cyclase and release of cyclic GMP

Red blood cells (RBCs) mediate cardioprotection via nitric oxide–like bioactivity, but the signaling and the identity of any mediator released by the RBCs remains unknown. We investigated whether RBCs exposed to hypoxia release a cardioprotective mediator and explored the nature of this mediator. Pe...

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Detalles Bibliográficos
Autores principales: Yang, Jiangning, Sundqvist, Michaela L., Zheng, Xiaowei, Jiao, Tong, Collado, Aida, Tratsiakovich, Yahor, Mahdi, Ali, Tengbom, John, Mergia, Evanthia, Catrina, Sergiu-Bogdan, Zhou, Zhichao, Carlström, Mattias, Akaike, Takaaki, Cortese-Krott, Miriam M., Weitzberg, Eddie, Lundberg, Jon O., Pernow, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10471167/
https://www.ncbi.nlm.nih.gov/pubmed/37655658
http://dx.doi.org/10.1172/JCI167693

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