The latent reservoir of inducible, infectious HIV-1 does not decrease despite decades of antiretroviral therapy

HIV-1 persists in a latent reservoir in resting CD4(+) T cells despite antiretroviral therapy (ART). The reservoir decays slowly over the first 7 years of ART (t(1/2) = 44 months). However, whether decay continues with long-term ART is unclear. Recent integration site studies indicate gradual select...

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Detalles Bibliográficos
Autores principales: McMyn, Natalie F., Varriale, Joseph, Fray, Emily J., Zitzmann, Carolin, MacLeod, Hannah, Lai, Jun, Singhal, Anushka, Moskovljevic, Milica, Garcia, Mauro A., Lopez, Brianna M., Hariharan, Vivek, Rhodehouse, Kyle, Lynn, Kenneth, Tebas, Pablo, Mounzer, Karam, Montaner, Luis J., Benko, Erika, Kovacs, Colin, Hoh, Rebecca, Simonetti, Francesco R., Laird, Gregory M., Deeks, Steven G., Ribeiro, Ruy M., Perelson, Alan S., Siliciano, Robert F., Siliciano, Janet M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10471168/
https://www.ncbi.nlm.nih.gov/pubmed/37463049
http://dx.doi.org/10.1172/JCI171554

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