Autotaxin suppresses cytotoxic T cells via LPAR5 to promote anti–PD-1 resistance in non–small cell lung cancer

Non–small cell lung cancers that harbor concurrent KRAS and TP53 (KP) mutations are immunologically warm tumors with partial responsiveness to anti–PD-(L)1 blockade; however, most patients observe little or no durable clinical benefit. To identify novel tumor-driven resistance mechanisms, we develop...

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Detalles Bibliográficos
Autores principales: Konen, Jessica M., Rodriguez, B. Leticia, Wu, Haoyi, Fradette, Jared J., Gibson, Laura, Diao, Lixia, Wang, Jing, Schmidt, Stephanie, Wistuba, Ignacio I., Zhang, Jianjun, Gibbons, Don L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10471170/
https://www.ncbi.nlm.nih.gov/pubmed/37655662
http://dx.doi.org/10.1172/JCI163128

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10471170/
https://www.ncbi.nlm.nih.gov/pubmed/37655662
http://dx.doi.org/10.1172/JCI163128

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