SF3B1 mutation and ATM deletion codrive leukemogenesis via centromeric R-loop dysregulation

RNA splicing factor SF3B1 is recurrently mutated in various cancers, particularly in hematologic malignancies. We previously reported that coexpression of Sf3b1 mutation and Atm deletion in B cells, but not either lesion alone, leads to the onset of chronic lymphocytic leukemia (CLL) with CLL cells...

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Detalles Bibliográficos
Autores principales: Cusan, Martina, Shen, Haifeng, Zhang, Bo, Liao, Aijun, Yang, Lu, Jin, Meiling, Fernandez, Mike, Iyer, Prajish, Wu, Yiming, Hart, Kevyn, Gutierrez, Catherine, Nik, Sara, Pruett-Miller, Shondra M., Stark, Jeremy, Obeng, Esther A., Bowman, Teresa V., Wu, Catherine J., Lin, Ren-Jang, Wang, Lili
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10471171/
https://www.ncbi.nlm.nih.gov/pubmed/37463047
http://dx.doi.org/10.1172/JCI163325

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