Immune checkpoint blockade induces distinct alterations in the microenvironments of primary and metastatic brain tumors

In comparison with responses in recurrent glioblastoma (rGBM), the intracranial response of brain metastases (BrM) to immune checkpoint blockade (ICB) is less well studied. Here, we present an integrated single-cell RNA-Seq (scRNA-Seq) study of 19 ICB-naive and 9 ICB-treated BrM samples from our own...

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Detalles Bibliográficos
Autores principales: Sun, Lu, Kienzler, Jenny C., Reynoso, Jeremy G., Lee, Alexander, Shiuan, Eileen, Li, Shanpeng, Kim, Jiyoon, Ding, Lizhong, Monteleone, Amber J., Owens, Geoffrey C., Phillips, Joanna J., Everson, Richard G., Nathanson, David, Cloughesy, Timothy F., Li, Gang, Liau, Linda M., Hugo, Willy, Kim, Won, Prins, Robert M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10471177/
https://www.ncbi.nlm.nih.gov/pubmed/37655659
http://dx.doi.org/10.1172/JCI169314

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