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Impact of multidisciplinary team on the pattern of care for brain metastasis from breast cancer
PURPOSE: The aim of this study was to explore how a multidisciplinary team (MDT) affects patterns of local or systematic treatment. METHODS: We retrospectively reviewed the data of consecutive patients in the breast cancer with brain metastases (BCBM) database at our institution from January 2011 to...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10471195/ https://www.ncbi.nlm.nih.gov/pubmed/37664027 http://dx.doi.org/10.3389/fonc.2023.1160802 |
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author | Xu, Fei Ou, Dan Qi, Weixiang Wang, Shubei Han, Yiming Cai, Gang Cao, Lu Xu, Cheng Chen, Jia-Yi |
author_facet | Xu, Fei Ou, Dan Qi, Weixiang Wang, Shubei Han, Yiming Cai, Gang Cao, Lu Xu, Cheng Chen, Jia-Yi |
author_sort | Xu, Fei |
collection | PubMed |
description | PURPOSE: The aim of this study was to explore how a multidisciplinary team (MDT) affects patterns of local or systematic treatment. METHODS: We retrospectively reviewed the data of consecutive patients in the breast cancer with brain metastases (BCBM) database at our institution from January 2011 to April 2021. The patients were divided into an MDT group and a non-MDT group. RESULTS: A total of 208 patients were analyzed, including 104 each in the MDT and non-MDT groups. After MDT, 56 patients (53.8%) were found to have intracranial “diagnosis upgrade”. In the matched population, patients in the MDT group recorded a higher proportion of meningeal metastases (14.4% vs. 4.8%, p = 0.02), symptomatic tumor progression (11.5% vs. 5.8%, p = 0.04), and an increased number of occurrences of brain metastases (BM) progression (p < 0.05). Attending MDT was an independent factor associated with ≥2 courses of intracranial radiotherapy (RT) [odds ratio (OR) 5.4, 95% confidence interval (CI): 2.7–10.9, p < 0.001], novel RT technique use (7.0, 95% CI 3.5–14.0, p < 0.001), and prospective clinical research (OR 5.7, 95% CI 2.4–13.4, p < 0.001). CONCLUSION: Patients with complex conditions are often referred for MDT discussions. An MDT may improve the qualities of intracranial RT and systemic therapy, resulting in benefits of overall survival for BC patients after BM. This encourages the idea that treatment recommendations for patients with BMBC should be discussed within an MDT. |
format | Online Article Text |
id | pubmed-10471195 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-104711952023-09-01 Impact of multidisciplinary team on the pattern of care for brain metastasis from breast cancer Xu, Fei Ou, Dan Qi, Weixiang Wang, Shubei Han, Yiming Cai, Gang Cao, Lu Xu, Cheng Chen, Jia-Yi Front Oncol Oncology PURPOSE: The aim of this study was to explore how a multidisciplinary team (MDT) affects patterns of local or systematic treatment. METHODS: We retrospectively reviewed the data of consecutive patients in the breast cancer with brain metastases (BCBM) database at our institution from January 2011 to April 2021. The patients were divided into an MDT group and a non-MDT group. RESULTS: A total of 208 patients were analyzed, including 104 each in the MDT and non-MDT groups. After MDT, 56 patients (53.8%) were found to have intracranial “diagnosis upgrade”. In the matched population, patients in the MDT group recorded a higher proportion of meningeal metastases (14.4% vs. 4.8%, p = 0.02), symptomatic tumor progression (11.5% vs. 5.8%, p = 0.04), and an increased number of occurrences of brain metastases (BM) progression (p < 0.05). Attending MDT was an independent factor associated with ≥2 courses of intracranial radiotherapy (RT) [odds ratio (OR) 5.4, 95% confidence interval (CI): 2.7–10.9, p < 0.001], novel RT technique use (7.0, 95% CI 3.5–14.0, p < 0.001), and prospective clinical research (OR 5.7, 95% CI 2.4–13.4, p < 0.001). CONCLUSION: Patients with complex conditions are often referred for MDT discussions. An MDT may improve the qualities of intracranial RT and systemic therapy, resulting in benefits of overall survival for BC patients after BM. This encourages the idea that treatment recommendations for patients with BMBC should be discussed within an MDT. Frontiers Media S.A. 2023-08-16 /pmc/articles/PMC10471195/ /pubmed/37664027 http://dx.doi.org/10.3389/fonc.2023.1160802 Text en Copyright © 2023 Xu, Ou, Qi, Wang, Han, Cai, Cao, Xu and Chen https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oncology Xu, Fei Ou, Dan Qi, Weixiang Wang, Shubei Han, Yiming Cai, Gang Cao, Lu Xu, Cheng Chen, Jia-Yi Impact of multidisciplinary team on the pattern of care for brain metastasis from breast cancer |
title | Impact of multidisciplinary team on the pattern of care for brain metastasis from breast cancer |
title_full | Impact of multidisciplinary team on the pattern of care for brain metastasis from breast cancer |
title_fullStr | Impact of multidisciplinary team on the pattern of care for brain metastasis from breast cancer |
title_full_unstemmed | Impact of multidisciplinary team on the pattern of care for brain metastasis from breast cancer |
title_short | Impact of multidisciplinary team on the pattern of care for brain metastasis from breast cancer |
title_sort | impact of multidisciplinary team on the pattern of care for brain metastasis from breast cancer |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10471195/ https://www.ncbi.nlm.nih.gov/pubmed/37664027 http://dx.doi.org/10.3389/fonc.2023.1160802 |
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