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Selection of iPSCs without mtDNA deletion for autologous cell therapy in a patient with Pearson syndrome

Screening for genetic defects in the cells should be examined for clinical application. The Pearson syndrome (PS) patient harbored nuclear mutations in the POLG and SSBP1 genes, which could induce systemic large-scale mitochondrial genome (mtDNA) deletion. We investigated iPSCs with mtDNA deletions...

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Detalles Bibliográficos
Autores principales:	Lee, Yeonmi, Han, Jongsuk, Hwang, Sae-Byeok, Kang, Soon-Suk, Son, Hyeoung-Bin, Jin, Chaeyeon, Kim, Jae Eun, Lee, Beom Hee, Kang, Eunju
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Korean Society for Biochemistry and Molecular Biology 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10471463/ https://www.ncbi.nlm.nih.gov/pubmed/37156631 http://dx.doi.org/10.5483/BMBRep.2022-0204

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