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Changes in Cerebral Blood Flow in Patients Who Receive Different Durations of Hemodialysis: An Arterial Spin Labeling MRI Study
BACKGROUND AND PURPOSE: This study aimed to determine the changes in cerebral blood flow (CBF) in patients who received different durations of hemodialysis (HD) using arterial spin labeling magnetic resonance imaging. METHODS: The study included 46 patients who received HD and 24 demographically sim...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Korean Neurological Association
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10471545/ https://www.ncbi.nlm.nih.gov/pubmed/37455502 http://dx.doi.org/10.3988/jcn.2022.0357 |
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author | Xue, Yan Wu, Zhuanzhuan Li, Bo Sun, Gang Jia, Fengyu Liu, Kai |
author_facet | Xue, Yan Wu, Zhuanzhuan Li, Bo Sun, Gang Jia, Fengyu Liu, Kai |
author_sort | Xue, Yan |
collection | PubMed |
description | BACKGROUND AND PURPOSE: This study aimed to determine the changes in cerebral blood flow (CBF) in patients who received different durations of hemodialysis (HD) using arterial spin labeling magnetic resonance imaging. METHODS: The study included 46 patients who received HD and 24 demographically similar healthy controls (HCs). Patients who received HD were divided into three subgroups based on its duration: HD-1 (n=15, dialysis duration ≤24 months), HD-2 (n=16, dialysis duration >24 and ≤72 months), and HD-3 (n=15, dialysis duration ≥73 months). All subjects completed the Mini Mental State Examination and Montreal Cognitive Assessment tests, and the patients who received HD underwent laboratory tests. Group-level differences in the global and regional CBFs between patients who received HD and HCs were assessed. Correlation analysis was performed to evaluate the associations among CBF, clinical variables, and cognitive function. RESULTS: Compared with HCs, global and regional CBFs were significantly increased in the HD-1 and HD-2 groups (p<0.05), but there was no significant difference in the HD-3 group (p>0.05). However, compared with the HD-1 group, the HD-3 group had significantly decreased global and regional CBFs (p<0.05). The cognitive function was worse in patients who received long-term HD than in HCs. Increased dialysis duration and hemoglobin level were predictive risk factors for decreased CBF in patients who received long-term HD. CONCLUSIONS: Patients who received long-term HD with normal CBF had worse cognitive function, which may be related to increased dialysis duration. |
format | Online Article Text |
id | pubmed-10471545 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Korean Neurological Association |
record_format | MEDLINE/PubMed |
spelling | pubmed-104715452023-09-02 Changes in Cerebral Blood Flow in Patients Who Receive Different Durations of Hemodialysis: An Arterial Spin Labeling MRI Study Xue, Yan Wu, Zhuanzhuan Li, Bo Sun, Gang Jia, Fengyu Liu, Kai J Clin Neurol Original Article BACKGROUND AND PURPOSE: This study aimed to determine the changes in cerebral blood flow (CBF) in patients who received different durations of hemodialysis (HD) using arterial spin labeling magnetic resonance imaging. METHODS: The study included 46 patients who received HD and 24 demographically similar healthy controls (HCs). Patients who received HD were divided into three subgroups based on its duration: HD-1 (n=15, dialysis duration ≤24 months), HD-2 (n=16, dialysis duration >24 and ≤72 months), and HD-3 (n=15, dialysis duration ≥73 months). All subjects completed the Mini Mental State Examination and Montreal Cognitive Assessment tests, and the patients who received HD underwent laboratory tests. Group-level differences in the global and regional CBFs between patients who received HD and HCs were assessed. Correlation analysis was performed to evaluate the associations among CBF, clinical variables, and cognitive function. RESULTS: Compared with HCs, global and regional CBFs were significantly increased in the HD-1 and HD-2 groups (p<0.05), but there was no significant difference in the HD-3 group (p>0.05). However, compared with the HD-1 group, the HD-3 group had significantly decreased global and regional CBFs (p<0.05). The cognitive function was worse in patients who received long-term HD than in HCs. Increased dialysis duration and hemoglobin level were predictive risk factors for decreased CBF in patients who received long-term HD. CONCLUSIONS: Patients who received long-term HD with normal CBF had worse cognitive function, which may be related to increased dialysis duration. Korean Neurological Association 2023-09 2023-04-18 /pmc/articles/PMC10471545/ /pubmed/37455502 http://dx.doi.org/10.3988/jcn.2022.0357 Text en Copyright © 2023 Korean Neurological Association https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0 (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Xue, Yan Wu, Zhuanzhuan Li, Bo Sun, Gang Jia, Fengyu Liu, Kai Changes in Cerebral Blood Flow in Patients Who Receive Different Durations of Hemodialysis: An Arterial Spin Labeling MRI Study |
title | Changes in Cerebral Blood Flow in Patients Who Receive Different Durations of Hemodialysis: An Arterial Spin Labeling MRI Study |
title_full | Changes in Cerebral Blood Flow in Patients Who Receive Different Durations of Hemodialysis: An Arterial Spin Labeling MRI Study |
title_fullStr | Changes in Cerebral Blood Flow in Patients Who Receive Different Durations of Hemodialysis: An Arterial Spin Labeling MRI Study |
title_full_unstemmed | Changes in Cerebral Blood Flow in Patients Who Receive Different Durations of Hemodialysis: An Arterial Spin Labeling MRI Study |
title_short | Changes in Cerebral Blood Flow in Patients Who Receive Different Durations of Hemodialysis: An Arterial Spin Labeling MRI Study |
title_sort | changes in cerebral blood flow in patients who receive different durations of hemodialysis: an arterial spin labeling mri study |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10471545/ https://www.ncbi.nlm.nih.gov/pubmed/37455502 http://dx.doi.org/10.3988/jcn.2022.0357 |
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