Portosystemic shunt placement reveals blood signatures for the development of hepatic encephalopathy through mass spectrometry

Elective transjugular intrahepatic portosystemic shunt (TIPS) placement can worsen cognitive dysfunction in hepatic encephalopathy (HE) patients due to toxins, including possible microbial metabolites, entering the systemic circulation. We conducted untargeted metabolomics on a prospective cohort of...

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Autores principales: Dantas Machado, Ana Carolina, Ramos, Stephany Flores, Gauglitz, Julia M., Fassler, Anne-Marie, Petras, Daniel, Aksenov, Alexander A., Kim, Un Bi, Lazarowicz, Michael, Barnard Giustini, Abbey, Aryafar, Hamed, Vodkin, Irine, Warren, Curtis, Dorrestein, Pieter C., Zarrinpar, Ali, Zarrinpar, Amir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10471626/
https://www.ncbi.nlm.nih.gov/pubmed/37652904
http://dx.doi.org/10.1038/s41467-023-40741-9
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author Dantas Machado, Ana Carolina
Ramos, Stephany Flores
Gauglitz, Julia M.
Fassler, Anne-Marie
Petras, Daniel
Aksenov, Alexander A.
Kim, Un Bi
Lazarowicz, Michael
Barnard Giustini, Abbey
Aryafar, Hamed
Vodkin, Irine
Warren, Curtis
Dorrestein, Pieter C.
Zarrinpar, Ali
Zarrinpar, Amir
author_facet Dantas Machado, Ana Carolina
Ramos, Stephany Flores
Gauglitz, Julia M.
Fassler, Anne-Marie
Petras, Daniel
Aksenov, Alexander A.
Kim, Un Bi
Lazarowicz, Michael
Barnard Giustini, Abbey
Aryafar, Hamed
Vodkin, Irine
Warren, Curtis
Dorrestein, Pieter C.
Zarrinpar, Ali
Zarrinpar, Amir
author_sort Dantas Machado, Ana Carolina
collection PubMed
description Elective transjugular intrahepatic portosystemic shunt (TIPS) placement can worsen cognitive dysfunction in hepatic encephalopathy (HE) patients due to toxins, including possible microbial metabolites, entering the systemic circulation. We conducted untargeted metabolomics on a prospective cohort of 22 patients with cirrhosis undergoing elective TIPS placement and followed them up to one year post TIPS for HE development. Here we suggest that pre-existing intrahepatic shunting predicts HE severity post-TIPS. Bile acid levels decrease in the peripheral vein post-TIPS, and the abundances of three specific conjugated di- and tri-hydroxylated bile acids are inversely correlated with HE grade. Bilirubins and glycerophosphocholines undergo chemical modifications pre- to post-TIPS and based on HE grade. Our results suggest that TIPS-induced metabolome changes can impact HE development, and that pre-existing intrahepatic shunting could be used to predict HE severity post-TIPS.
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spelling pubmed-104716262023-09-02 Portosystemic shunt placement reveals blood signatures for the development of hepatic encephalopathy through mass spectrometry Dantas Machado, Ana Carolina Ramos, Stephany Flores Gauglitz, Julia M. Fassler, Anne-Marie Petras, Daniel Aksenov, Alexander A. Kim, Un Bi Lazarowicz, Michael Barnard Giustini, Abbey Aryafar, Hamed Vodkin, Irine Warren, Curtis Dorrestein, Pieter C. Zarrinpar, Ali Zarrinpar, Amir Nat Commun Article Elective transjugular intrahepatic portosystemic shunt (TIPS) placement can worsen cognitive dysfunction in hepatic encephalopathy (HE) patients due to toxins, including possible microbial metabolites, entering the systemic circulation. We conducted untargeted metabolomics on a prospective cohort of 22 patients with cirrhosis undergoing elective TIPS placement and followed them up to one year post TIPS for HE development. Here we suggest that pre-existing intrahepatic shunting predicts HE severity post-TIPS. Bile acid levels decrease in the peripheral vein post-TIPS, and the abundances of three specific conjugated di- and tri-hydroxylated bile acids are inversely correlated with HE grade. Bilirubins and glycerophosphocholines undergo chemical modifications pre- to post-TIPS and based on HE grade. Our results suggest that TIPS-induced metabolome changes can impact HE development, and that pre-existing intrahepatic shunting could be used to predict HE severity post-TIPS. Nature Publishing Group UK 2023-08-31 /pmc/articles/PMC10471626/ /pubmed/37652904 http://dx.doi.org/10.1038/s41467-023-40741-9 Text en © This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Dantas Machado, Ana Carolina
Ramos, Stephany Flores
Gauglitz, Julia M.
Fassler, Anne-Marie
Petras, Daniel
Aksenov, Alexander A.
Kim, Un Bi
Lazarowicz, Michael
Barnard Giustini, Abbey
Aryafar, Hamed
Vodkin, Irine
Warren, Curtis
Dorrestein, Pieter C.
Zarrinpar, Ali
Zarrinpar, Amir
Portosystemic shunt placement reveals blood signatures for the development of hepatic encephalopathy through mass spectrometry
title Portosystemic shunt placement reveals blood signatures for the development of hepatic encephalopathy through mass spectrometry
title_full Portosystemic shunt placement reveals blood signatures for the development of hepatic encephalopathy through mass spectrometry
title_fullStr Portosystemic shunt placement reveals blood signatures for the development of hepatic encephalopathy through mass spectrometry
title_full_unstemmed Portosystemic shunt placement reveals blood signatures for the development of hepatic encephalopathy through mass spectrometry
title_short Portosystemic shunt placement reveals blood signatures for the development of hepatic encephalopathy through mass spectrometry
title_sort portosystemic shunt placement reveals blood signatures for the development of hepatic encephalopathy through mass spectrometry
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10471626/
https://www.ncbi.nlm.nih.gov/pubmed/37652904
http://dx.doi.org/10.1038/s41467-023-40741-9
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