The dysregulation of miRNAs in epilepsy and their regulatory role in inflammation and apoptosis

Epilepsy is a neurological disorder that impacts millions of people worldwide, and it is characterized by the occurrence of recurrent seizures. The pathogenesis of epilepsy is complex, involving dysregulation of various genes and signaling pathways. MicroRNAs (miRNAs) are a group of small non-coding...

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Autores principales: Xie, Guoping, Chen, Huan, He, Chan, Hu, Siheng, Xiao, Xue, Luo, Qunying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10471759/
https://www.ncbi.nlm.nih.gov/pubmed/37653173
http://dx.doi.org/10.1007/s10142-023-01220-y
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author Xie, Guoping
Chen, Huan
He, Chan
Hu, Siheng
Xiao, Xue
Luo, Qunying
author_facet Xie, Guoping
Chen, Huan
He, Chan
Hu, Siheng
Xiao, Xue
Luo, Qunying
author_sort Xie, Guoping
collection PubMed
description Epilepsy is a neurological disorder that impacts millions of people worldwide, and it is characterized by the occurrence of recurrent seizures. The pathogenesis of epilepsy is complex, involving dysregulation of various genes and signaling pathways. MicroRNAs (miRNAs) are a group of small non-coding RNAs that play a vital role in the regulation of gene expression. They have been found to be involved in the pathogenesis of epilepsy, acting as key regulators of neuronal excitability and synaptic plasticity. In recent years, there has been a growing interest in exploring the miRNA regulatory network in epilepsy. This review summarizes the current knowledge of the regulatory miRNAs involved in inflammation and apoptosis in epilepsy and discusses its potential as a new avenue for developing targeted therapies for the treatment of epilepsy.
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spelling pubmed-104717592023-09-02 The dysregulation of miRNAs in epilepsy and their regulatory role in inflammation and apoptosis Xie, Guoping Chen, Huan He, Chan Hu, Siheng Xiao, Xue Luo, Qunying Funct Integr Genomics Review Epilepsy is a neurological disorder that impacts millions of people worldwide, and it is characterized by the occurrence of recurrent seizures. The pathogenesis of epilepsy is complex, involving dysregulation of various genes and signaling pathways. MicroRNAs (miRNAs) are a group of small non-coding RNAs that play a vital role in the regulation of gene expression. They have been found to be involved in the pathogenesis of epilepsy, acting as key regulators of neuronal excitability and synaptic plasticity. In recent years, there has been a growing interest in exploring the miRNA regulatory network in epilepsy. This review summarizes the current knowledge of the regulatory miRNAs involved in inflammation and apoptosis in epilepsy and discusses its potential as a new avenue for developing targeted therapies for the treatment of epilepsy. Springer Berlin Heidelberg 2023-08-31 2023 /pmc/articles/PMC10471759/ /pubmed/37653173 http://dx.doi.org/10.1007/s10142-023-01220-y Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review
Xie, Guoping
Chen, Huan
He, Chan
Hu, Siheng
Xiao, Xue
Luo, Qunying
The dysregulation of miRNAs in epilepsy and their regulatory role in inflammation and apoptosis
title The dysregulation of miRNAs in epilepsy and their regulatory role in inflammation and apoptosis
title_full The dysregulation of miRNAs in epilepsy and their regulatory role in inflammation and apoptosis
title_fullStr The dysregulation of miRNAs in epilepsy and their regulatory role in inflammation and apoptosis
title_full_unstemmed The dysregulation of miRNAs in epilepsy and their regulatory role in inflammation and apoptosis
title_short The dysregulation of miRNAs in epilepsy and their regulatory role in inflammation and apoptosis
title_sort dysregulation of mirnas in epilepsy and their regulatory role in inflammation and apoptosis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10471759/
https://www.ncbi.nlm.nih.gov/pubmed/37653173
http://dx.doi.org/10.1007/s10142-023-01220-y
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