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Small-cell neuroendocrine tumor of the bladder: Unexpected long-term survival with carboplatin-etoposide therapy in a patient with metastatic stage disease
Neuroendocrine small-cell bladder cancer is an extremely rare and aggressive entity, it constitutes <1% of all bladder malignancies. The small-cell neuroendocrine histological variant has a worse prognosis than the classical subtypes. A case of a 53-year-old female consulting with gross hematuria...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer - Medknow
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10471807/ https://www.ncbi.nlm.nih.gov/pubmed/37664100 http://dx.doi.org/10.4103/ua.ua_106_22 |
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author | Rico, Eduardo J. García Polledo, Luis Enrique Ortega Pellejero, Alejandro Sánchez Valdés, Sonia Vázquez Fernandez, Isabel Montuenga |
author_facet | Rico, Eduardo J. García Polledo, Luis Enrique Ortega Pellejero, Alejandro Sánchez Valdés, Sonia Vázquez Fernandez, Isabel Montuenga |
author_sort | Rico, Eduardo J. García |
collection | PubMed |
description | Neuroendocrine small-cell bladder cancer is an extremely rare and aggressive entity, it constitutes <1% of all bladder malignancies. The small-cell neuroendocrine histological variant has a worse prognosis than the classical subtypes. A case of a 53-year-old female consulting with gross hematuria is presented. Cystoscopy revealed a solid aspect lesion involving the posterior wall and dome that was resected. Histopathological findings showed small-cell pure variant carcinoma, high grade, with lymph, vascular, and perineural infiltration, infiltrating the muscle layer. The extension study made by hole body computed tomography scan, showed evidence of multiple lymph nodes and multiple visceral radiological involvements, with pulmonary, hepatic, and peritoneal implants. More than 10 years later, after receiving nine cycles of carboplatin-etoposide remains in complete remission and without radiological evidence of the disease. This is, to our knowledge, one of the longest disease-free survival cases in metastatic small-cell bladder cancer published nowadays. |
format | Online Article Text |
id | pubmed-10471807 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Wolters Kluwer - Medknow |
record_format | MEDLINE/PubMed |
spelling | pubmed-104718072023-09-02 Small-cell neuroendocrine tumor of the bladder: Unexpected long-term survival with carboplatin-etoposide therapy in a patient with metastatic stage disease Rico, Eduardo J. García Polledo, Luis Enrique Ortega Pellejero, Alejandro Sánchez Valdés, Sonia Vázquez Fernandez, Isabel Montuenga Urol Ann Case Report Neuroendocrine small-cell bladder cancer is an extremely rare and aggressive entity, it constitutes <1% of all bladder malignancies. The small-cell neuroendocrine histological variant has a worse prognosis than the classical subtypes. A case of a 53-year-old female consulting with gross hematuria is presented. Cystoscopy revealed a solid aspect lesion involving the posterior wall and dome that was resected. Histopathological findings showed small-cell pure variant carcinoma, high grade, with lymph, vascular, and perineural infiltration, infiltrating the muscle layer. The extension study made by hole body computed tomography scan, showed evidence of multiple lymph nodes and multiple visceral radiological involvements, with pulmonary, hepatic, and peritoneal implants. More than 10 years later, after receiving nine cycles of carboplatin-etoposide remains in complete remission and without radiological evidence of the disease. This is, to our knowledge, one of the longest disease-free survival cases in metastatic small-cell bladder cancer published nowadays. Wolters Kluwer - Medknow 2023 2023-07-17 /pmc/articles/PMC10471807/ /pubmed/37664100 http://dx.doi.org/10.4103/ua.ua_106_22 Text en Copyright: © 2023 Urology Annals https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. |
spellingShingle | Case Report Rico, Eduardo J. García Polledo, Luis Enrique Ortega Pellejero, Alejandro Sánchez Valdés, Sonia Vázquez Fernandez, Isabel Montuenga Small-cell neuroendocrine tumor of the bladder: Unexpected long-term survival with carboplatin-etoposide therapy in a patient with metastatic stage disease |
title | Small-cell neuroendocrine tumor of the bladder: Unexpected long-term survival with carboplatin-etoposide therapy in a patient with metastatic stage disease |
title_full | Small-cell neuroendocrine tumor of the bladder: Unexpected long-term survival with carboplatin-etoposide therapy in a patient with metastatic stage disease |
title_fullStr | Small-cell neuroendocrine tumor of the bladder: Unexpected long-term survival with carboplatin-etoposide therapy in a patient with metastatic stage disease |
title_full_unstemmed | Small-cell neuroendocrine tumor of the bladder: Unexpected long-term survival with carboplatin-etoposide therapy in a patient with metastatic stage disease |
title_short | Small-cell neuroendocrine tumor of the bladder: Unexpected long-term survival with carboplatin-etoposide therapy in a patient with metastatic stage disease |
title_sort | small-cell neuroendocrine tumor of the bladder: unexpected long-term survival with carboplatin-etoposide therapy in a patient with metastatic stage disease |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10471807/ https://www.ncbi.nlm.nih.gov/pubmed/37664100 http://dx.doi.org/10.4103/ua.ua_106_22 |
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