Serine-associated one-carbon metabolic reprogramming: a new anti-cancer therapeutic strategy

Tumour metabolism is a major focus of cancer research, and metabolic reprogramming is an important feature of malignant tumours. Serine is an important non-essential amino acid, which is a main resource of one-carbon units in tumours. Cancer cells proliferate more than normal cells and require more...

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Autores principales: Zhang, Jing, Bai, Jian, Gong, Chen, Wang, Jianhua, Cheng, Yi, Zhao, Jing, Xiong, Huihua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10471886/
https://www.ncbi.nlm.nih.gov/pubmed/37664062
http://dx.doi.org/10.3389/fonc.2023.1184626
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author Zhang, Jing
Bai, Jian
Gong, Chen
Wang, Jianhua
Cheng, Yi
Zhao, Jing
Xiong, Huihua
author_facet Zhang, Jing
Bai, Jian
Gong, Chen
Wang, Jianhua
Cheng, Yi
Zhao, Jing
Xiong, Huihua
author_sort Zhang, Jing
collection PubMed
description Tumour metabolism is a major focus of cancer research, and metabolic reprogramming is an important feature of malignant tumours. Serine is an important non-essential amino acid, which is a main resource of one-carbon units in tumours. Cancer cells proliferate more than normal cells and require more serine for proliferation. The cancer-related genes that are involved in serine metabolism also show changes corresponding to metabolic alterations. Here, we reviewed the serine-associated one-carbon metabolism and its potential as a target for anti-tumour therapeutic strategies.
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spelling pubmed-104718862023-09-02 Serine-associated one-carbon metabolic reprogramming: a new anti-cancer therapeutic strategy Zhang, Jing Bai, Jian Gong, Chen Wang, Jianhua Cheng, Yi Zhao, Jing Xiong, Huihua Front Oncol Oncology Tumour metabolism is a major focus of cancer research, and metabolic reprogramming is an important feature of malignant tumours. Serine is an important non-essential amino acid, which is a main resource of one-carbon units in tumours. Cancer cells proliferate more than normal cells and require more serine for proliferation. The cancer-related genes that are involved in serine metabolism also show changes corresponding to metabolic alterations. Here, we reviewed the serine-associated one-carbon metabolism and its potential as a target for anti-tumour therapeutic strategies. Frontiers Media S.A. 2023-08-18 /pmc/articles/PMC10471886/ /pubmed/37664062 http://dx.doi.org/10.3389/fonc.2023.1184626 Text en Copyright © 2023 Zhang, Bai, Gong, Wang, Cheng, Zhao and Xiong https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Zhang, Jing
Bai, Jian
Gong, Chen
Wang, Jianhua
Cheng, Yi
Zhao, Jing
Xiong, Huihua
Serine-associated one-carbon metabolic reprogramming: a new anti-cancer therapeutic strategy
title Serine-associated one-carbon metabolic reprogramming: a new anti-cancer therapeutic strategy
title_full Serine-associated one-carbon metabolic reprogramming: a new anti-cancer therapeutic strategy
title_fullStr Serine-associated one-carbon metabolic reprogramming: a new anti-cancer therapeutic strategy
title_full_unstemmed Serine-associated one-carbon metabolic reprogramming: a new anti-cancer therapeutic strategy
title_short Serine-associated one-carbon metabolic reprogramming: a new anti-cancer therapeutic strategy
title_sort serine-associated one-carbon metabolic reprogramming: a new anti-cancer therapeutic strategy
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10471886/
https://www.ncbi.nlm.nih.gov/pubmed/37664062
http://dx.doi.org/10.3389/fonc.2023.1184626
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