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Systemic virus infection results in CD8 T cell recruitment to the retina in the absence of local virus infection

During recent years, evidence has emerged that immune privileged sites such as the CNS and the retina may be more integrated in the systemic response to infection than was previously believed. In line with this, it was recently shown that a systemic acute virus infection leads to infiltration of CD8...

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Autores principales: Paskeviciute, Egle, Chen, Mei, Xu, Heping, Honoré, Bent, Vorum, Henrik, Sørensen, Torben Lykke, Christensen, Jan Pravsgaard, Thomsen, Allan Randrup, Nissen, Mogens Holst, Steffensen, Maria Abildgaard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10471971/
https://www.ncbi.nlm.nih.gov/pubmed/37662932
http://dx.doi.org/10.3389/fimmu.2023.1221511
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author Paskeviciute, Egle
Chen, Mei
Xu, Heping
Honoré, Bent
Vorum, Henrik
Sørensen, Torben Lykke
Christensen, Jan Pravsgaard
Thomsen, Allan Randrup
Nissen, Mogens Holst
Steffensen, Maria Abildgaard
author_facet Paskeviciute, Egle
Chen, Mei
Xu, Heping
Honoré, Bent
Vorum, Henrik
Sørensen, Torben Lykke
Christensen, Jan Pravsgaard
Thomsen, Allan Randrup
Nissen, Mogens Holst
Steffensen, Maria Abildgaard
author_sort Paskeviciute, Egle
collection PubMed
description During recent years, evidence has emerged that immune privileged sites such as the CNS and the retina may be more integrated in the systemic response to infection than was previously believed. In line with this, it was recently shown that a systemic acute virus infection leads to infiltration of CD8 T cells in the brains of immunocompetent mice. In this study, we extend these findings to the neurological tissue of the eye, namely the retina. We show that an acute systemic virus infection in mice leads to a transient CD8 T cell infiltration in the retina that is not directed by virus infection inside the retina. CD8 T cells were found throughout the retinal tissue, and had a high expression of CXCR6 and CXCR3, as also reported for tissue residing CD8 T cells in the lung and liver. We also show that the pigment epithelium lining the retina expresses CXCL16 (the ligand for CXCR6) similar to epithelial cells of the lung. Thus, our results suggest that the retina undergoes immune surveillance during a systemic infection, and that this surveillance appears to be directed by mechanisms similar to those described for non-privileged tissues.
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spelling pubmed-104719712023-09-02 Systemic virus infection results in CD8 T cell recruitment to the retina in the absence of local virus infection Paskeviciute, Egle Chen, Mei Xu, Heping Honoré, Bent Vorum, Henrik Sørensen, Torben Lykke Christensen, Jan Pravsgaard Thomsen, Allan Randrup Nissen, Mogens Holst Steffensen, Maria Abildgaard Front Immunol Immunology During recent years, evidence has emerged that immune privileged sites such as the CNS and the retina may be more integrated in the systemic response to infection than was previously believed. In line with this, it was recently shown that a systemic acute virus infection leads to infiltration of CD8 T cells in the brains of immunocompetent mice. In this study, we extend these findings to the neurological tissue of the eye, namely the retina. We show that an acute systemic virus infection in mice leads to a transient CD8 T cell infiltration in the retina that is not directed by virus infection inside the retina. CD8 T cells were found throughout the retinal tissue, and had a high expression of CXCR6 and CXCR3, as also reported for tissue residing CD8 T cells in the lung and liver. We also show that the pigment epithelium lining the retina expresses CXCL16 (the ligand for CXCR6) similar to epithelial cells of the lung. Thus, our results suggest that the retina undergoes immune surveillance during a systemic infection, and that this surveillance appears to be directed by mechanisms similar to those described for non-privileged tissues. Frontiers Media S.A. 2023-08-18 /pmc/articles/PMC10471971/ /pubmed/37662932 http://dx.doi.org/10.3389/fimmu.2023.1221511 Text en Copyright © 2023 Paskeviciute, Chen, Xu, Honoré, Vorum, Sørensen, Christensen, Thomsen, Nissen and Steffensen https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Paskeviciute, Egle
Chen, Mei
Xu, Heping
Honoré, Bent
Vorum, Henrik
Sørensen, Torben Lykke
Christensen, Jan Pravsgaard
Thomsen, Allan Randrup
Nissen, Mogens Holst
Steffensen, Maria Abildgaard
Systemic virus infection results in CD8 T cell recruitment to the retina in the absence of local virus infection
title Systemic virus infection results in CD8 T cell recruitment to the retina in the absence of local virus infection
title_full Systemic virus infection results in CD8 T cell recruitment to the retina in the absence of local virus infection
title_fullStr Systemic virus infection results in CD8 T cell recruitment to the retina in the absence of local virus infection
title_full_unstemmed Systemic virus infection results in CD8 T cell recruitment to the retina in the absence of local virus infection
title_short Systemic virus infection results in CD8 T cell recruitment to the retina in the absence of local virus infection
title_sort systemic virus infection results in cd8 t cell recruitment to the retina in the absence of local virus infection
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10471971/
https://www.ncbi.nlm.nih.gov/pubmed/37662932
http://dx.doi.org/10.3389/fimmu.2023.1221511
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