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Amide proton transfer-weighted magnetic resonance imaging for the differentiation of parotid gland tumors

PURPOSE: To assess the usefulness of amide proton transfer-weighted (APTw) imaging in the differentiation of parotid gland tumors. MATERIALS AND METHODS: Patients with parotid gland tumors who underwent APTw imaging were retrospectively enrolled and divided into groups according to pathology. Two ra...

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Autores principales: Wang, Yihua, Wang, Lijun, Huang, Haitao, Ma, Juntao, Lin, Liangjie, Liu, Lin, Song, Qingwei, Liu, Ailian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10471989/
https://www.ncbi.nlm.nih.gov/pubmed/37664057
http://dx.doi.org/10.3389/fonc.2023.1223598
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author Wang, Yihua
Wang, Lijun
Huang, Haitao
Ma, Juntao
Lin, Liangjie
Liu, Lin
Song, Qingwei
Liu, Ailian
author_facet Wang, Yihua
Wang, Lijun
Huang, Haitao
Ma, Juntao
Lin, Liangjie
Liu, Lin
Song, Qingwei
Liu, Ailian
author_sort Wang, Yihua
collection PubMed
description PURPOSE: To assess the usefulness of amide proton transfer-weighted (APTw) imaging in the differentiation of parotid gland tumors. MATERIALS AND METHODS: Patients with parotid gland tumors who underwent APTw imaging were retrospectively enrolled and divided into groups according to pathology. Two radiologists evaluated the APTw image quality independently, and APTw images with quality score ≥3 were enrolled. The maximum and average values of APTw imaging for tumor lesions (APTmax and APTmean) were measured. The differences in APTmax and APTmean were compared between malignant tumors (MTs) and benign tumors (BTs), as well as between MTs and pleomorphic adenomas (PAs) and between MTs and Warthin tumors (WTs). Independent-samples t-test, Kruskal–Wallis H test, and receiver operating characteristic (ROC) curve analyses were used for statistical analysis. RESULTS: Seventy-three patients were included for image quality evaluation. In this study, 32/73 and 29/73 parotid tumors were scored as 4 and 3, respectively. After excluding lesions with quality score ≤2 (12/73), the APTmean and APTmax of MTs were 4.15% ± 1.33% and 7.43% ± 1.61%, higher than those of BTs 2.74% ± 1.04% and 5.25% ± 1.54%, respectively (p < 0.05). The areas under the ROC curve (AUCs) of the APTmean and APTmax for differentiation between MTs and BTs were 0.819 and 0.821, respectively. MTs indicated significantly higher APTmean and APTmax values than those of PAs (p < 0.05) and WTs (p < 0.05). The AUCs of the APTmean and APTmax for differentiation between MTs and PAs were 0.830 and 0.815 and between MTs and WTs were 0.847 and 0.920, respectively. CONCLUSION: Most APTw images for parotid tumors had acceptable image quality for APTw value evaluation. Both APTmax and APTmean can be used to differentiate MTs from BTs and to differentiate MTs from subtype parotid gland tumors.
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spelling pubmed-104719892023-09-02 Amide proton transfer-weighted magnetic resonance imaging for the differentiation of parotid gland tumors Wang, Yihua Wang, Lijun Huang, Haitao Ma, Juntao Lin, Liangjie Liu, Lin Song, Qingwei Liu, Ailian Front Oncol Oncology PURPOSE: To assess the usefulness of amide proton transfer-weighted (APTw) imaging in the differentiation of parotid gland tumors. MATERIALS AND METHODS: Patients with parotid gland tumors who underwent APTw imaging were retrospectively enrolled and divided into groups according to pathology. Two radiologists evaluated the APTw image quality independently, and APTw images with quality score ≥3 were enrolled. The maximum and average values of APTw imaging for tumor lesions (APTmax and APTmean) were measured. The differences in APTmax and APTmean were compared between malignant tumors (MTs) and benign tumors (BTs), as well as between MTs and pleomorphic adenomas (PAs) and between MTs and Warthin tumors (WTs). Independent-samples t-test, Kruskal–Wallis H test, and receiver operating characteristic (ROC) curve analyses were used for statistical analysis. RESULTS: Seventy-three patients were included for image quality evaluation. In this study, 32/73 and 29/73 parotid tumors were scored as 4 and 3, respectively. After excluding lesions with quality score ≤2 (12/73), the APTmean and APTmax of MTs were 4.15% ± 1.33% and 7.43% ± 1.61%, higher than those of BTs 2.74% ± 1.04% and 5.25% ± 1.54%, respectively (p < 0.05). The areas under the ROC curve (AUCs) of the APTmean and APTmax for differentiation between MTs and BTs were 0.819 and 0.821, respectively. MTs indicated significantly higher APTmean and APTmax values than those of PAs (p < 0.05) and WTs (p < 0.05). The AUCs of the APTmean and APTmax for differentiation between MTs and PAs were 0.830 and 0.815 and between MTs and WTs were 0.847 and 0.920, respectively. CONCLUSION: Most APTw images for parotid tumors had acceptable image quality for APTw value evaluation. Both APTmax and APTmean can be used to differentiate MTs from BTs and to differentiate MTs from subtype parotid gland tumors. Frontiers Media S.A. 2023-08-18 /pmc/articles/PMC10471989/ /pubmed/37664057 http://dx.doi.org/10.3389/fonc.2023.1223598 Text en Copyright © 2023 Wang, Wang, Huang, Ma, Lin, Liu, Song and Liu https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Wang, Yihua
Wang, Lijun
Huang, Haitao
Ma, Juntao
Lin, Liangjie
Liu, Lin
Song, Qingwei
Liu, Ailian
Amide proton transfer-weighted magnetic resonance imaging for the differentiation of parotid gland tumors
title Amide proton transfer-weighted magnetic resonance imaging for the differentiation of parotid gland tumors
title_full Amide proton transfer-weighted magnetic resonance imaging for the differentiation of parotid gland tumors
title_fullStr Amide proton transfer-weighted magnetic resonance imaging for the differentiation of parotid gland tumors
title_full_unstemmed Amide proton transfer-weighted magnetic resonance imaging for the differentiation of parotid gland tumors
title_short Amide proton transfer-weighted magnetic resonance imaging for the differentiation of parotid gland tumors
title_sort amide proton transfer-weighted magnetic resonance imaging for the differentiation of parotid gland tumors
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10471989/
https://www.ncbi.nlm.nih.gov/pubmed/37664057
http://dx.doi.org/10.3389/fonc.2023.1223598
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