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Beyond Neoantigens: Antigens Derived from Tumor Drivers as Cancer Vaccine Targets
A vaccine targeting HER2, a nonmutated but overexpressed tumor antigen, readily primed T cells for ex vivo expansion and adoptive transfer with minimal toxicity. This regimen led to intramolecular epitope spreading in a majority of patients and offers a treatment modality that may improve outcomes f...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Association for Cancer Research
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10472089/ https://www.ncbi.nlm.nih.gov/pubmed/37428103 http://dx.doi.org/10.1158/1078-0432.CCR-23-1244 |