FDG PET/CT and thyroid biopsy leads to neurosarcoidosis diagnosis

We present a unique case of neurosarcoidosis diagnosed based on thyroid biopsy and FDG PET (Fluorodeoxyglucose positron emission tomography) imaging. A patient presented for a second opinion after being placed in hospice for rapidly progressing dementia, presumed to be due to Creutzfeldt Jakob disea...

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Autores principales: Bullock, Catherine, McCann, Matthew, Sharma, Akash, Young, Jason R., Metcalfe, Allie M., Parent, Ephraim E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10472138/
https://www.ncbi.nlm.nih.gov/pubmed/37663559
http://dx.doi.org/10.1016/j.radcr.2023.08.005
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author Bullock, Catherine
McCann, Matthew
Sharma, Akash
Young, Jason R.
Metcalfe, Allie M.
Parent, Ephraim E.
author_facet Bullock, Catherine
McCann, Matthew
Sharma, Akash
Young, Jason R.
Metcalfe, Allie M.
Parent, Ephraim E.
author_sort Bullock, Catherine
collection PubMed
description We present a unique case of neurosarcoidosis diagnosed based on thyroid biopsy and FDG PET (Fluorodeoxyglucose positron emission tomography) imaging. A patient presented for a second opinion after being placed in hospice for rapidly progressing dementia, presumed to be due to Creutzfeldt Jakob disease despite negative workup and was unable to perform activities of daily life or communicate with his wife. The patient underwent a workup including whole-body FDG PET, which showed hypermetabolic lymph nodes as well as a hypermetabolic nodule in the thyroid. Biopsy of the lymph nodes was nondiagnostic, but the thyroid biopsy tissue yielded a diagnosis of sarcoid. After ruling out other causes and reviewing the tissue pathology, the patient was diagnosed with systemic sarcoidosis with neurological involvement and started on infliximab with rapid improvement.
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spelling pubmed-104721382023-09-02 FDG PET/CT and thyroid biopsy leads to neurosarcoidosis diagnosis Bullock, Catherine McCann, Matthew Sharma, Akash Young, Jason R. Metcalfe, Allie M. Parent, Ephraim E. Radiol Case Rep Case Report We present a unique case of neurosarcoidosis diagnosed based on thyroid biopsy and FDG PET (Fluorodeoxyglucose positron emission tomography) imaging. A patient presented for a second opinion after being placed in hospice for rapidly progressing dementia, presumed to be due to Creutzfeldt Jakob disease despite negative workup and was unable to perform activities of daily life or communicate with his wife. The patient underwent a workup including whole-body FDG PET, which showed hypermetabolic lymph nodes as well as a hypermetabolic nodule in the thyroid. Biopsy of the lymph nodes was nondiagnostic, but the thyroid biopsy tissue yielded a diagnosis of sarcoid. After ruling out other causes and reviewing the tissue pathology, the patient was diagnosed with systemic sarcoidosis with neurological involvement and started on infliximab with rapid improvement. Elsevier 2023-08-28 /pmc/articles/PMC10472138/ /pubmed/37663559 http://dx.doi.org/10.1016/j.radcr.2023.08.005 Text en © 2023 The Authors. Published by Elsevier Inc. on behalf of University of Washington. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Bullock, Catherine
McCann, Matthew
Sharma, Akash
Young, Jason R.
Metcalfe, Allie M.
Parent, Ephraim E.
FDG PET/CT and thyroid biopsy leads to neurosarcoidosis diagnosis
title FDG PET/CT and thyroid biopsy leads to neurosarcoidosis diagnosis
title_full FDG PET/CT and thyroid biopsy leads to neurosarcoidosis diagnosis
title_fullStr FDG PET/CT and thyroid biopsy leads to neurosarcoidosis diagnosis
title_full_unstemmed FDG PET/CT and thyroid biopsy leads to neurosarcoidosis diagnosis
title_short FDG PET/CT and thyroid biopsy leads to neurosarcoidosis diagnosis
title_sort fdg pet/ct and thyroid biopsy leads to neurosarcoidosis diagnosis
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10472138/
https://www.ncbi.nlm.nih.gov/pubmed/37663559
http://dx.doi.org/10.1016/j.radcr.2023.08.005
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