IgG4-related disease and prostate cancer: A case report and review of the literature

We present a case of a patient with recurrent prostate cancer after treatment for favorable intermediate risk cancer. There was an exceptionally steep increase in PSA from <0.5 to 130ng/mL in 27 months accompanied with the development of bone metastasis. The PSA increase was unexpected. We suspec...

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Detalles Bibliográficos
Autores principales: Zekhnini, Adam, Taussky, Daniel, Lattouf, Jean-Baptiste, Koenig, Martial
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10472218/
https://www.ncbi.nlm.nih.gov/pubmed/37664531
http://dx.doi.org/10.1016/j.eucr.2023.102538
Descripción
Sumario:We present a case of a patient with recurrent prostate cancer after treatment for favorable intermediate risk cancer. There was an exceptionally steep increase in PSA from <0.5 to 130ng/mL in 27 months accompanied with the development of bone metastasis. The PSA increase was unexpected. We suspect that this unusual development of metastases must have been caused by an impairment of the immune system caused by his IgG4 disease, and this may have allowed residual prostate cancer cells in the prostate to spread quickly. The influence of IgG4 on cancer is debated.

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