IgG4-related disease and prostate cancer: A case report and review of the literature

We present a case of a patient with recurrent prostate cancer after treatment for favorable intermediate risk cancer. There was an exceptionally steep increase in PSA from <0.5 to 130ng/mL in 27 months accompanied with the development of bone metastasis. The PSA increase was unexpected. We suspec...

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Detalles Bibliográficos
Autores principales: Zekhnini, Adam, Taussky, Daniel, Lattouf, Jean-Baptiste, Koenig, Martial
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10472218/
https://www.ncbi.nlm.nih.gov/pubmed/37664531
http://dx.doi.org/10.1016/j.eucr.2023.102538
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author Zekhnini, Adam
Taussky, Daniel
Lattouf, Jean-Baptiste
Koenig, Martial
author_facet Zekhnini, Adam
Taussky, Daniel
Lattouf, Jean-Baptiste
Koenig, Martial
author_sort Zekhnini, Adam
collection PubMed
description We present a case of a patient with recurrent prostate cancer after treatment for favorable intermediate risk cancer. There was an exceptionally steep increase in PSA from <0.5 to 130ng/mL in 27 months accompanied with the development of bone metastasis. The PSA increase was unexpected. We suspect that this unusual development of metastases must have been caused by an impairment of the immune system caused by his IgG4 disease, and this may have allowed residual prostate cancer cells in the prostate to spread quickly. The influence of IgG4 on cancer is debated.
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spelling pubmed-104722182023-09-02 IgG4-related disease and prostate cancer: A case report and review of the literature Zekhnini, Adam Taussky, Daniel Lattouf, Jean-Baptiste Koenig, Martial Urol Case Rep Oncology We present a case of a patient with recurrent prostate cancer after treatment for favorable intermediate risk cancer. There was an exceptionally steep increase in PSA from <0.5 to 130ng/mL in 27 months accompanied with the development of bone metastasis. The PSA increase was unexpected. We suspect that this unusual development of metastases must have been caused by an impairment of the immune system caused by his IgG4 disease, and this may have allowed residual prostate cancer cells in the prostate to spread quickly. The influence of IgG4 on cancer is debated. Elsevier 2023-08-19 /pmc/articles/PMC10472218/ /pubmed/37664531 http://dx.doi.org/10.1016/j.eucr.2023.102538 Text en © 2023 The Authors https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Oncology
Zekhnini, Adam
Taussky, Daniel
Lattouf, Jean-Baptiste
Koenig, Martial
IgG4-related disease and prostate cancer: A case report and review of the literature
title IgG4-related disease and prostate cancer: A case report and review of the literature
title_full IgG4-related disease and prostate cancer: A case report and review of the literature
title_fullStr IgG4-related disease and prostate cancer: A case report and review of the literature
title_full_unstemmed IgG4-related disease and prostate cancer: A case report and review of the literature
title_short IgG4-related disease and prostate cancer: A case report and review of the literature
title_sort igg4-related disease and prostate cancer: a case report and review of the literature
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10472218/
https://www.ncbi.nlm.nih.gov/pubmed/37664531
http://dx.doi.org/10.1016/j.eucr.2023.102538
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