Mcl-1 deficiency in murine livers leads to nuclear polyploidisation and mitotic errors: Implications for hepatocellular carcinoma

BACKGROUND & AIMS: Mcl-1, an antiapoptotic protein overexpressed in many tumours, including hepatocellular carcinoma (HCC), represents a promising target for cancer treatment. Although Mcl-1 non-apoptotic roles might critically influence the therapeutic potential of Mcl-1 inhibitors, these funct...

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Detalles Bibliográficos
Autores principales: Clerbaux, Laure-Alix, Cordier, Pierre, Desboeufs, Nina, Unger, Kristian, Leary, Peter, Semere, Gabriel, Boege, Yannick, Chan, Lap Kwan, Desdouets, Chantal, Lopes, Massimo, Weber, Achim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10472239/
https://www.ncbi.nlm.nih.gov/pubmed/37663116
http://dx.doi.org/10.1016/j.jhepr.2023.100838

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