Small molecule nitroalkenes inhibit RAD51-mediated homologous recombination and amplify triple-negative breast cancer cell killing by DNA-directed therapies

Nitro fatty acids (NO(2)-FAs) are endogenously generated lipid signaling mediators from metabolic and inflammatory reactions between conjugated diene fatty acids and nitric oxide or nitrite-derived reactive species. NO(2)-FAs undergo reversible Michael addition with hyperreactive protein cysteine th...

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Detalles Bibliográficos
Autores principales: Hong, Lisa, Braden, Dennis C., Zhao, Yaoning, Skoko, John J., Chang, Fei, Woodcock, Steven R., Uvalle, Crystall, Casey, Allison, Wood, Katherine, Salvatore, Sonia R., Asan, Alparslan, Harkness, Trey, Fagunloye, Adeola, Razzaghi, Mortezaali, Straub, Adam, Spies, Maria, Brown, Daniel D., Lee, Adrian V., Schopfer, Francisco, Freeman, Bruce A., Neumann, Carola A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10472314/
https://www.ncbi.nlm.nih.gov/pubmed/37633047
http://dx.doi.org/10.1016/j.redox.2023.102856

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