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Ictal and interictal SPECT with (99m)Tc‐HMPAO in presurgical epilepsy. I: Predictive value and methodological considerations

OBJECTIVE: This retrospective study investigates the predictive value of ictal subtraction single‐photon emission computed tomography (SPECT) co‐registered to magnetic resonance imaging (MRI) (SISCOM) for successful epilepsy surgery. METHODS: 57 patients examined with SISCOM as a part of epilepsy su...

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Autores principales: Prener, Martin, Drejer, Veronica, Ziebell, Morten, Jensen, Per, Madsen, Camilla Gøbel, Olsen, Svitlana, Thomsen, Gerda, Pinborg, Lars H., Paulson, Olaf B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10472396/
https://www.ncbi.nlm.nih.gov/pubmed/37464953
http://dx.doi.org/10.1002/epi4.12786
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author Prener, Martin
Drejer, Veronica
Ziebell, Morten
Jensen, Per
Madsen, Camilla Gøbel
Olsen, Svitlana
Thomsen, Gerda
Pinborg, Lars H.
Paulson, Olaf B.
author_facet Prener, Martin
Drejer, Veronica
Ziebell, Morten
Jensen, Per
Madsen, Camilla Gøbel
Olsen, Svitlana
Thomsen, Gerda
Pinborg, Lars H.
Paulson, Olaf B.
author_sort Prener, Martin
collection PubMed
description OBJECTIVE: This retrospective study investigates the predictive value of ictal subtraction single‐photon emission computed tomography (SPECT) co‐registered to magnetic resonance imaging (MRI) (SISCOM) for successful epilepsy surgery. METHODS: 57 patients examined with SISCOM as a part of epilepsy surgery evaluation were divided into two groups based on seizure duration after tracer injection (group 1: Seizure duration above or equal to 30 s, group 2: Seizure duration under 30 s). SISCOM was compared to the surgical site and categorized as good or poor concordance. Subsequently, Odds ratios (ORs) and positive predictive values (PPVs) were calculated for each group for good surgical outcome, freedom from disabling seizures. RESULTS: The PPVs and ORs for good surgical outcome was 74.1% and 5.71 for group 1 and 40% and 0.22 for group 2. SISCOM had a similar positive predictive value regardless of whether the focus was in the same or neighboring lobe, but same hemisphere as the resection. CONCLUSION: In conclusion, the implementation of a precise definition for a well‐executed ictal SPECT scan with respect to seizure duration after injection enhances the positive predictive value (PPV) and odds ratio (OR) for successful surgical outcome, surpassing previous findings, whether the focus in resected lobe or the neighboring.
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spelling pubmed-104723962023-09-02 Ictal and interictal SPECT with (99m)Tc‐HMPAO in presurgical epilepsy. I: Predictive value and methodological considerations Prener, Martin Drejer, Veronica Ziebell, Morten Jensen, Per Madsen, Camilla Gøbel Olsen, Svitlana Thomsen, Gerda Pinborg, Lars H. Paulson, Olaf B. Epilepsia Open Original Articles OBJECTIVE: This retrospective study investigates the predictive value of ictal subtraction single‐photon emission computed tomography (SPECT) co‐registered to magnetic resonance imaging (MRI) (SISCOM) for successful epilepsy surgery. METHODS: 57 patients examined with SISCOM as a part of epilepsy surgery evaluation were divided into two groups based on seizure duration after tracer injection (group 1: Seizure duration above or equal to 30 s, group 2: Seizure duration under 30 s). SISCOM was compared to the surgical site and categorized as good or poor concordance. Subsequently, Odds ratios (ORs) and positive predictive values (PPVs) were calculated for each group for good surgical outcome, freedom from disabling seizures. RESULTS: The PPVs and ORs for good surgical outcome was 74.1% and 5.71 for group 1 and 40% and 0.22 for group 2. SISCOM had a similar positive predictive value regardless of whether the focus was in the same or neighboring lobe, but same hemisphere as the resection. CONCLUSION: In conclusion, the implementation of a precise definition for a well‐executed ictal SPECT scan with respect to seizure duration after injection enhances the positive predictive value (PPV) and odds ratio (OR) for successful surgical outcome, surpassing previous findings, whether the focus in resected lobe or the neighboring. John Wiley and Sons Inc. 2023-07-25 /pmc/articles/PMC10472396/ /pubmed/37464953 http://dx.doi.org/10.1002/epi4.12786 Text en © 2023 The Authors. Epilepsia Open published by Wiley Periodicals LLC on behalf of International League Against Epilepsy. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
Prener, Martin
Drejer, Veronica
Ziebell, Morten
Jensen, Per
Madsen, Camilla Gøbel
Olsen, Svitlana
Thomsen, Gerda
Pinborg, Lars H.
Paulson, Olaf B.
Ictal and interictal SPECT with (99m)Tc‐HMPAO in presurgical epilepsy. I: Predictive value and methodological considerations
title Ictal and interictal SPECT with (99m)Tc‐HMPAO in presurgical epilepsy. I: Predictive value and methodological considerations
title_full Ictal and interictal SPECT with (99m)Tc‐HMPAO in presurgical epilepsy. I: Predictive value and methodological considerations
title_fullStr Ictal and interictal SPECT with (99m)Tc‐HMPAO in presurgical epilepsy. I: Predictive value and methodological considerations
title_full_unstemmed Ictal and interictal SPECT with (99m)Tc‐HMPAO in presurgical epilepsy. I: Predictive value and methodological considerations
title_short Ictal and interictal SPECT with (99m)Tc‐HMPAO in presurgical epilepsy. I: Predictive value and methodological considerations
title_sort ictal and interictal spect with (99m)tc‐hmpao in presurgical epilepsy. i: predictive value and methodological considerations
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10472396/
https://www.ncbi.nlm.nih.gov/pubmed/37464953
http://dx.doi.org/10.1002/epi4.12786
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