Blood virome of patients with traumatic sepsis

Sepsis is one of the possible outcomes of severe trauma, and it poses a dire threat to human life, particularly in immunocompromised people. The most prevalent pathogens are bacteria and fungi, but viruses should not be overlooked. For viral metagenomic analysis, we collected blood samples from eigh...

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Autores principales: Mao, Qingqing, Liu, Ying, Zhang, Ju, Li, Wang, Zhang, Wen, Zhou, Chenglin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10472630/
https://www.ncbi.nlm.nih.gov/pubmed/37658428
http://dx.doi.org/10.1186/s12985-023-02162-4
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author Mao, Qingqing
Liu, Ying
Zhang, Ju
Li, Wang
Zhang, Wen
Zhou, Chenglin
author_facet Mao, Qingqing
Liu, Ying
Zhang, Ju
Li, Wang
Zhang, Wen
Zhou, Chenglin
author_sort Mao, Qingqing
collection PubMed
description Sepsis is one of the possible outcomes of severe trauma, and it poses a dire threat to human life, particularly in immunocompromised people. The most prevalent pathogens are bacteria and fungi, but viruses should not be overlooked. For viral metagenomic analysis, we collected blood samples from eight patients with post-traumatic sepsis before and seven days after treatment. The results demonstrated that Anellovirus predominated the viral community, followed by Siphoviridae and Myoviridae, and that the variations in viral community and viral load before and after treatment were not statistically significant. This study allows us to investigate methods for establishing NGS-based viral diagnostic instruments for detecting viral infections in the blood of sepsis patients so that antiviral therapy can be administered quickly. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12985-023-02162-4.
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spelling pubmed-104726302023-09-02 Blood virome of patients with traumatic sepsis Mao, Qingqing Liu, Ying Zhang, Ju Li, Wang Zhang, Wen Zhou, Chenglin Virol J Research Sepsis is one of the possible outcomes of severe trauma, and it poses a dire threat to human life, particularly in immunocompromised people. The most prevalent pathogens are bacteria and fungi, but viruses should not be overlooked. For viral metagenomic analysis, we collected blood samples from eight patients with post-traumatic sepsis before and seven days after treatment. The results demonstrated that Anellovirus predominated the viral community, followed by Siphoviridae and Myoviridae, and that the variations in viral community and viral load before and after treatment were not statistically significant. This study allows us to investigate methods for establishing NGS-based viral diagnostic instruments for detecting viral infections in the blood of sepsis patients so that antiviral therapy can be administered quickly. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12985-023-02162-4. BioMed Central 2023-09-01 /pmc/articles/PMC10472630/ /pubmed/37658428 http://dx.doi.org/10.1186/s12985-023-02162-4 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Mao, Qingqing
Liu, Ying
Zhang, Ju
Li, Wang
Zhang, Wen
Zhou, Chenglin
Blood virome of patients with traumatic sepsis
title Blood virome of patients with traumatic sepsis
title_full Blood virome of patients with traumatic sepsis
title_fullStr Blood virome of patients with traumatic sepsis
title_full_unstemmed Blood virome of patients with traumatic sepsis
title_short Blood virome of patients with traumatic sepsis
title_sort blood virome of patients with traumatic sepsis
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10472630/
https://www.ncbi.nlm.nih.gov/pubmed/37658428
http://dx.doi.org/10.1186/s12985-023-02162-4
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