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Expanding Arsenal against Neurodegenerative Diseases Using Quercetin Based Nanoformulations: Breakthroughs and Bottlenecks
Quercetin (Qu), a dietary flavonoid, is obtained from many fruits and vegetables such as coriander, broccoli, capers, asparagus, onion, figs, radish leaves, cranberry, walnuts, and citrus fruits. It has proven its role as a nutraceutical owing to numerous pharmacological effects against various dise...
Autores principales: | , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Bentham Science Publishers
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10472810/ https://www.ncbi.nlm.nih.gov/pubmed/35950245 http://dx.doi.org/10.2174/1570159X20666220810105421 |
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author | Vishwas, Sukriti Kumar, Rajesh Khursheed, Rubiya Ramanunny, Arya Kadukkattil Kumar, Rajan Awasthi, Ankit Corrie, Leander Porwal, Omji Arshad, Mohammed F. Alshammari, Mohammed Kanan Alghitran, Abdulrahman A. Qumayri, Ashwaq N. Alkhaldi, Saif M. Alshammari, Abdulaziz Khalaf Chellappan, Dinesh Kumar Gupta, Gaurav Collet, Trudi Adams, Jon Dua, Kamal Gulati, Monica Singh, Sachin Kumar |
author_facet | Vishwas, Sukriti Kumar, Rajesh Khursheed, Rubiya Ramanunny, Arya Kadukkattil Kumar, Rajan Awasthi, Ankit Corrie, Leander Porwal, Omji Arshad, Mohammed F. Alshammari, Mohammed Kanan Alghitran, Abdulrahman A. Qumayri, Ashwaq N. Alkhaldi, Saif M. Alshammari, Abdulaziz Khalaf Chellappan, Dinesh Kumar Gupta, Gaurav Collet, Trudi Adams, Jon Dua, Kamal Gulati, Monica Singh, Sachin Kumar |
author_sort | Vishwas, Sukriti |
collection | PubMed |
description | Quercetin (Qu), a dietary flavonoid, is obtained from many fruits and vegetables such as coriander, broccoli, capers, asparagus, onion, figs, radish leaves, cranberry, walnuts, and citrus fruits. It has proven its role as a nutraceutical owing to numerous pharmacological effects against various diseases in preclinical studies. Despite these facts, Qu and its nanoparticles are less explored in clinical research as a nutraceutical. The present review covers various neuroprotective actions of Qu against various neurodegenerative diseases (NDs) such as Alzheimer’s, Parkinson’s, Huntington’s, and Amyotrophic lateral sclerosis. A literature search was conducted to systematically review the various mechanistic pathways through which Qu elicits its neuroprotective actions and the challenges associated with raw Qu that compromise therapeutic efficacy. The nanoformulations developed to enhance Qu’s therapeutic efficacy are also covered. Various ongoing/completed clinical trials related to Qu in treating various diseases, including NDs, are also tabulated. Despite these many successes, the exploration of research on Qu-loaded nanoformulations is limited mostly to preclinical studies, probably due to poor drug loading and stability of the formulation, time-consuming steps involved in the formulation, and their poor scale-up capacity. Hence, future efforts are required in this area to reach Qu nanoformulations to the clinical level. |
format | Online Article Text |
id | pubmed-10472810 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Bentham Science Publishers |
record_format | MEDLINE/PubMed |
spelling | pubmed-104728102023-11-18 Expanding Arsenal against Neurodegenerative Diseases Using Quercetin Based Nanoformulations: Breakthroughs and Bottlenecks Vishwas, Sukriti Kumar, Rajesh Khursheed, Rubiya Ramanunny, Arya Kadukkattil Kumar, Rajan Awasthi, Ankit Corrie, Leander Porwal, Omji Arshad, Mohammed F. Alshammari, Mohammed Kanan Alghitran, Abdulrahman A. Qumayri, Ashwaq N. Alkhaldi, Saif M. Alshammari, Abdulaziz Khalaf Chellappan, Dinesh Kumar Gupta, Gaurav Collet, Trudi Adams, Jon Dua, Kamal Gulati, Monica Singh, Sachin Kumar Curr Neuropharmacol Medicine, Neurology, Pharmacology, Neuroscience Quercetin (Qu), a dietary flavonoid, is obtained from many fruits and vegetables such as coriander, broccoli, capers, asparagus, onion, figs, radish leaves, cranberry, walnuts, and citrus fruits. It has proven its role as a nutraceutical owing to numerous pharmacological effects against various diseases in preclinical studies. Despite these facts, Qu and its nanoparticles are less explored in clinical research as a nutraceutical. The present review covers various neuroprotective actions of Qu against various neurodegenerative diseases (NDs) such as Alzheimer’s, Parkinson’s, Huntington’s, and Amyotrophic lateral sclerosis. A literature search was conducted to systematically review the various mechanistic pathways through which Qu elicits its neuroprotective actions and the challenges associated with raw Qu that compromise therapeutic efficacy. The nanoformulations developed to enhance Qu’s therapeutic efficacy are also covered. Various ongoing/completed clinical trials related to Qu in treating various diseases, including NDs, are also tabulated. Despite these many successes, the exploration of research on Qu-loaded nanoformulations is limited mostly to preclinical studies, probably due to poor drug loading and stability of the formulation, time-consuming steps involved in the formulation, and their poor scale-up capacity. Hence, future efforts are required in this area to reach Qu nanoformulations to the clinical level. Bentham Science Publishers 2023-05-18 2023-05-18 /pmc/articles/PMC10472810/ /pubmed/35950245 http://dx.doi.org/10.2174/1570159X20666220810105421 Text en © 2023 Bentham Science Publishers https://creativecommons.org/licenses/by/4.0/© 2023 The Author(s). Published by Bentham Science Publisher. This is an open access article published under CC BY 4.0 https://creativecommons.org/licenses/by/4.0/legalcode) |
spellingShingle | Medicine, Neurology, Pharmacology, Neuroscience Vishwas, Sukriti Kumar, Rajesh Khursheed, Rubiya Ramanunny, Arya Kadukkattil Kumar, Rajan Awasthi, Ankit Corrie, Leander Porwal, Omji Arshad, Mohammed F. Alshammari, Mohammed Kanan Alghitran, Abdulrahman A. Qumayri, Ashwaq N. Alkhaldi, Saif M. Alshammari, Abdulaziz Khalaf Chellappan, Dinesh Kumar Gupta, Gaurav Collet, Trudi Adams, Jon Dua, Kamal Gulati, Monica Singh, Sachin Kumar Expanding Arsenal against Neurodegenerative Diseases Using Quercetin Based Nanoformulations: Breakthroughs and Bottlenecks |
title | Expanding Arsenal against Neurodegenerative Diseases Using Quercetin Based Nanoformulations: Breakthroughs and Bottlenecks |
title_full | Expanding Arsenal against Neurodegenerative Diseases Using Quercetin Based Nanoformulations: Breakthroughs and Bottlenecks |
title_fullStr | Expanding Arsenal against Neurodegenerative Diseases Using Quercetin Based Nanoformulations: Breakthroughs and Bottlenecks |
title_full_unstemmed | Expanding Arsenal against Neurodegenerative Diseases Using Quercetin Based Nanoformulations: Breakthroughs and Bottlenecks |
title_short | Expanding Arsenal against Neurodegenerative Diseases Using Quercetin Based Nanoformulations: Breakthroughs and Bottlenecks |
title_sort | expanding arsenal against neurodegenerative diseases using quercetin based nanoformulations: breakthroughs and bottlenecks |
topic | Medicine, Neurology, Pharmacology, Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10472810/ https://www.ncbi.nlm.nih.gov/pubmed/35950245 http://dx.doi.org/10.2174/1570159X20666220810105421 |
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