Melatonin suppresses Akt/mTOR/S6K activity, induces cell apoptosis, and synergistically inhibits cell growth with sunitinib in renal carcinoma cells via reversing Warburg effect

BACKGROUND: Metabolic alteration drives renal cell carcinoma (RCC) development, while the impact of melatonin (MLT), a neurohormone secreted during darkness, on RCC cell growth and underlying mechanisms remains unclear. METHODS: We detected concentration of metabolites through metabolomic analyses u...

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Detalles Bibliográficos
Autores principales: Xue, Kai-Hua, Jiang, Yi-Fan, Bai, Ji-Yu, Zhang, Di-Ze, Chen, Yu-Hang, Ma, Jian-Bin, Zhu, Zhi-Jing, Wang, Xinyang, Guo, Peng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10472857/
https://www.ncbi.nlm.nih.gov/pubmed/37642220
http://dx.doi.org/10.1080/13510002.2023.2251234

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10472857/
https://www.ncbi.nlm.nih.gov/pubmed/37642220
http://dx.doi.org/10.1080/13510002.2023.2251234

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