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Incidence, prevalence, and comorbidities of chronic pancreatitis: A 7-year population-based study
BACKGROUND: Chronic pancreatitis (CP) is a fibroinflammatory syndrome leading to reduced quality of life and shortened life expectancy. Population-based estimates of the incidence, prevalence, and comorbidities of CP in China are scarce. AIM: To characterize the incidence, prevalence, and comorbidit...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Baishideng Publishing Group Inc
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10472896/ https://www.ncbi.nlm.nih.gov/pubmed/37662860 http://dx.doi.org/10.3748/wjg.v29.i30.4671 |
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author | Cai, Qiu-Yu Tan, Kun Zhang, Xue-Li Han, Xu Pan, Jing-Ping Huang, Zhi-Yin Tang, Cheng-Wei Li, Jing |
author_facet | Cai, Qiu-Yu Tan, Kun Zhang, Xue-Li Han, Xu Pan, Jing-Ping Huang, Zhi-Yin Tang, Cheng-Wei Li, Jing |
author_sort | Cai, Qiu-Yu |
collection | PubMed |
description | BACKGROUND: Chronic pancreatitis (CP) is a fibroinflammatory syndrome leading to reduced quality of life and shortened life expectancy. Population-based estimates of the incidence, prevalence, and comorbidities of CP in China are scarce. AIM: To characterize the incidence, prevalence, and comorbidities of CP in Sichuan Province, China, with population-based data. METHODS: Data on CP from 2015 to 2021 were obtained from the Health Information Center of Sichuan Province. During the study period, a total of 38090 individuals were diagnosed with CP in Sichuan Province. The yearly incidence rate and point prevalence rate (December 31, 2021) of CP were calculated. The prevalence of comorbid conditions in CP patients was estimated. The annual number of CP-related hospitalizations, hospital length of stay, and hospitalization costs for CP were evaluated. Yearly incidence rates were standardized for age by the direct method using the permanent population of Sichuan Province in the 2020 census as the standard population. An analysis of variance test for the linearity of scaled variables and the Cochran-Armitage trend test for categorical data were performed to investigate the yearly trends, and a two-sided test with P < 0.05 was considered statistically significant. RESULTS: The 38090 CP patients comprised 23280 males and 14810 females. The mean age of patients at CP diagnosis was 57.83 years, with male patients (55.87 years) being younger than female patients (60.11 years) (P < 0.001). The mean incidence rate of CP during the study period was 6.81 per 100000 person-years, and the incidence of CP increased each year, from 4.03 per 100000 person-years in 2015 to 8.27 per 100000 person-years in 2021 (P < 0.001). The point prevalence rate of CP in 2021 was 45.52 per 100000 individuals for the total population, with rates of 55.04 per 100000 individuals for men and 35.78 per 100000 individuals for women (P < 0.001). Individuals aged 65 years or older had the highest prevalence of CP (113.38 per 100000 individuals) (P < 0.001). Diabetes (26.32%) was the most common comorbidity in CP patients. The number of CP-related hospitalizations increased from 3739 in 2015 to 11009 in 2021. The total costs for CP-related hospitalizations for CP patients over the study period were 667.96 million yuan, with an average of 17538 yuan per patient. CONCLUSION: The yearly incidence of CP is increasing, and the overall CP hospitalization cost has increased by 1.4 times during the last 7 years, indicating that CP remains a heavy health burden. |
format | Online Article Text |
id | pubmed-10472896 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Baishideng Publishing Group Inc |
record_format | MEDLINE/PubMed |
spelling | pubmed-104728962023-09-02 Incidence, prevalence, and comorbidities of chronic pancreatitis: A 7-year population-based study Cai, Qiu-Yu Tan, Kun Zhang, Xue-Li Han, Xu Pan, Jing-Ping Huang, Zhi-Yin Tang, Cheng-Wei Li, Jing World J Gastroenterol Observational Study BACKGROUND: Chronic pancreatitis (CP) is a fibroinflammatory syndrome leading to reduced quality of life and shortened life expectancy. Population-based estimates of the incidence, prevalence, and comorbidities of CP in China are scarce. AIM: To characterize the incidence, prevalence, and comorbidities of CP in Sichuan Province, China, with population-based data. METHODS: Data on CP from 2015 to 2021 were obtained from the Health Information Center of Sichuan Province. During the study period, a total of 38090 individuals were diagnosed with CP in Sichuan Province. The yearly incidence rate and point prevalence rate (December 31, 2021) of CP were calculated. The prevalence of comorbid conditions in CP patients was estimated. The annual number of CP-related hospitalizations, hospital length of stay, and hospitalization costs for CP were evaluated. Yearly incidence rates were standardized for age by the direct method using the permanent population of Sichuan Province in the 2020 census as the standard population. An analysis of variance test for the linearity of scaled variables and the Cochran-Armitage trend test for categorical data were performed to investigate the yearly trends, and a two-sided test with P < 0.05 was considered statistically significant. RESULTS: The 38090 CP patients comprised 23280 males and 14810 females. The mean age of patients at CP diagnosis was 57.83 years, with male patients (55.87 years) being younger than female patients (60.11 years) (P < 0.001). The mean incidence rate of CP during the study period was 6.81 per 100000 person-years, and the incidence of CP increased each year, from 4.03 per 100000 person-years in 2015 to 8.27 per 100000 person-years in 2021 (P < 0.001). The point prevalence rate of CP in 2021 was 45.52 per 100000 individuals for the total population, with rates of 55.04 per 100000 individuals for men and 35.78 per 100000 individuals for women (P < 0.001). Individuals aged 65 years or older had the highest prevalence of CP (113.38 per 100000 individuals) (P < 0.001). Diabetes (26.32%) was the most common comorbidity in CP patients. The number of CP-related hospitalizations increased from 3739 in 2015 to 11009 in 2021. The total costs for CP-related hospitalizations for CP patients over the study period were 667.96 million yuan, with an average of 17538 yuan per patient. CONCLUSION: The yearly incidence of CP is increasing, and the overall CP hospitalization cost has increased by 1.4 times during the last 7 years, indicating that CP remains a heavy health burden. Baishideng Publishing Group Inc 2023-08-14 2023-08-14 /pmc/articles/PMC10472896/ /pubmed/37662860 http://dx.doi.org/10.3748/wjg.v29.i30.4671 Text en ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. https://creativecommons.org/licenses/by-nc/4.0/This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
spellingShingle | Observational Study Cai, Qiu-Yu Tan, Kun Zhang, Xue-Li Han, Xu Pan, Jing-Ping Huang, Zhi-Yin Tang, Cheng-Wei Li, Jing Incidence, prevalence, and comorbidities of chronic pancreatitis: A 7-year population-based study |
title | Incidence, prevalence, and comorbidities of chronic pancreatitis: A 7-year population-based study |
title_full | Incidence, prevalence, and comorbidities of chronic pancreatitis: A 7-year population-based study |
title_fullStr | Incidence, prevalence, and comorbidities of chronic pancreatitis: A 7-year population-based study |
title_full_unstemmed | Incidence, prevalence, and comorbidities of chronic pancreatitis: A 7-year population-based study |
title_short | Incidence, prevalence, and comorbidities of chronic pancreatitis: A 7-year population-based study |
title_sort | incidence, prevalence, and comorbidities of chronic pancreatitis: a 7-year population-based study |
topic | Observational Study |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10472896/ https://www.ncbi.nlm.nih.gov/pubmed/37662860 http://dx.doi.org/10.3748/wjg.v29.i30.4671 |
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