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Pitfalls and promises of bile duct alternatives: There is plenty of room in the regenerative surgery
Current abdominal surgery has several approaches for biliary reconstruction. However, the creation of functional and clinically applicable bile duct substitutes still represents an unmet need. In the paper by Miyazawa and colleagues, approaches to the creation of bile duct alternatives were summariz...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Baishideng Publishing Group Inc
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10472900/ https://www.ncbi.nlm.nih.gov/pubmed/37662863 http://dx.doi.org/10.3748/wjg.v29.i30.4701 |
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author | Klabukov, Ilya D Baranovskii, Denis S Shegay, Peter V Kaprin, Andrey D |
author_facet | Klabukov, Ilya D Baranovskii, Denis S Shegay, Peter V Kaprin, Andrey D |
author_sort | Klabukov, Ilya D |
collection | PubMed |
description | Current abdominal surgery has several approaches for biliary reconstruction. However, the creation of functional and clinically applicable bile duct substitutes still represents an unmet need. In the paper by Miyazawa and colleagues, approaches to the creation of bile duct alternatives were summarized, and the reasons for the lack of development in this area were explained. The history of bile duct surgery since the nineteenth century was also traced, leading to the conclusion that the use of bioabsorbable materials holds promise for the creation of bile duct substitutes in the future. We suggest three ideas that may stimulate progress in the field of bile duct substitute creation. First, a systematic analysis of the causative factors leading to failure or success in the creation of bile duct substitutes may help to develop more effective approaches. Second, the regeneration of a bile duct is delicately balanced between epithelialization and subsequent submucosal maturation within limited time frames, which may be more apparent when using quantitative models to estimate outcomes. Third, the utilization of the organism’s endogenous regeneration abilities may enhance the creation of bile duct substitutes. We are convinced that an interdisciplinary approach, including quantitative methods, machine learning, and deep retrospective analysis of the causes that led to success and failure in studies on the creation of bile duct substitutes, holds great value. Additionally, more attention should be directed towards the balance of epithelialization and submucosal maturation rates, as well as induced angiogenesis. These ideas deserve further investigation to pave the way for bile duct restoration with physiologically relevant outcomes. |
format | Online Article Text |
id | pubmed-10472900 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Baishideng Publishing Group Inc |
record_format | MEDLINE/PubMed |
spelling | pubmed-104729002023-09-02 Pitfalls and promises of bile duct alternatives: There is plenty of room in the regenerative surgery Klabukov, Ilya D Baranovskii, Denis S Shegay, Peter V Kaprin, Andrey D World J Gastroenterol Letter to the Editor Current abdominal surgery has several approaches for biliary reconstruction. However, the creation of functional and clinically applicable bile duct substitutes still represents an unmet need. In the paper by Miyazawa and colleagues, approaches to the creation of bile duct alternatives were summarized, and the reasons for the lack of development in this area were explained. The history of bile duct surgery since the nineteenth century was also traced, leading to the conclusion that the use of bioabsorbable materials holds promise for the creation of bile duct substitutes in the future. We suggest three ideas that may stimulate progress in the field of bile duct substitute creation. First, a systematic analysis of the causative factors leading to failure or success in the creation of bile duct substitutes may help to develop more effective approaches. Second, the regeneration of a bile duct is delicately balanced between epithelialization and subsequent submucosal maturation within limited time frames, which may be more apparent when using quantitative models to estimate outcomes. Third, the utilization of the organism’s endogenous regeneration abilities may enhance the creation of bile duct substitutes. We are convinced that an interdisciplinary approach, including quantitative methods, machine learning, and deep retrospective analysis of the causes that led to success and failure in studies on the creation of bile duct substitutes, holds great value. Additionally, more attention should be directed towards the balance of epithelialization and submucosal maturation rates, as well as induced angiogenesis. These ideas deserve further investigation to pave the way for bile duct restoration with physiologically relevant outcomes. Baishideng Publishing Group Inc 2023-08-14 2023-08-14 /pmc/articles/PMC10472900/ /pubmed/37662863 http://dx.doi.org/10.3748/wjg.v29.i30.4701 Text en ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. https://creativecommons.org/licenses/by-nc/4.0/This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
spellingShingle | Letter to the Editor Klabukov, Ilya D Baranovskii, Denis S Shegay, Peter V Kaprin, Andrey D Pitfalls and promises of bile duct alternatives: There is plenty of room in the regenerative surgery |
title | Pitfalls and promises of bile duct alternatives: There is plenty of room in the regenerative surgery |
title_full | Pitfalls and promises of bile duct alternatives: There is plenty of room in the regenerative surgery |
title_fullStr | Pitfalls and promises of bile duct alternatives: There is plenty of room in the regenerative surgery |
title_full_unstemmed | Pitfalls and promises of bile duct alternatives: There is plenty of room in the regenerative surgery |
title_short | Pitfalls and promises of bile duct alternatives: There is plenty of room in the regenerative surgery |
title_sort | pitfalls and promises of bile duct alternatives: there is plenty of room in the regenerative surgery |
topic | Letter to the Editor |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10472900/ https://www.ncbi.nlm.nih.gov/pubmed/37662863 http://dx.doi.org/10.3748/wjg.v29.i30.4701 |
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