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Neuroprotective Effect of Phloretin in Rotenone-Induced Mice Model of Parkinson’s Disease: Modulating mTOR-NRF2-p62 Mediated Autophagy-Oxidative Stress Crosstalk

BACKGROUND: Parkinson’s disease (PD) is an age-related progressive multifactorial, neurodegenerative disease. The autophagy and Keap1-Nrf2 axis system are both implicated in the oxidative-stress response, metabolic stress, and innate immunity, and their dysregulation is associated with pathogenic pr...

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Detalles Bibliográficos
Autores principales:	Shirgadwar, Shubhendu M., Kumar, Rahul, Preeti, Kumari, Khatri, Dharmendra Kumar, Singh, Shashi Bala
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	IOS Press 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10473071/ https://www.ncbi.nlm.nih.gov/pubmed/36463449 http://dx.doi.org/10.3233/JAD-220793

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