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Parkinson’s Disease Case Ascertainment in the Sister Study: A Cohort for Environmental Health Research

BACKGROUND: Large prospective studies are essential for investigating the environmental causes of Parkinson’s disease (PD), but PD diagnosis via clinical exams is often infeasible in such studies. OBJECTIVE: To present case ascertainment strategy and data collection in a US cohort of women. METHODS:...

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Autores principales: Cao, Zichun, Song, Shengfang, Huang, Xuemei, Li, Chenxi, Luo, Zhehui, D’Aloisio, Aimee A., Suarez, Lourdes, Hernandez, Dena G., Singleton, Andrew B., Sandler, Dale P., Chen, Honglei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10473078/
https://www.ncbi.nlm.nih.gov/pubmed/37334620
http://dx.doi.org/10.3233/JPD-230053
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author Cao, Zichun
Song, Shengfang
Huang, Xuemei
Li, Chenxi
Luo, Zhehui
D’Aloisio, Aimee A.
Suarez, Lourdes
Hernandez, Dena G.
Singleton, Andrew B.
Sandler, Dale P.
Chen, Honglei
author_facet Cao, Zichun
Song, Shengfang
Huang, Xuemei
Li, Chenxi
Luo, Zhehui
D’Aloisio, Aimee A.
Suarez, Lourdes
Hernandez, Dena G.
Singleton, Andrew B.
Sandler, Dale P.
Chen, Honglei
author_sort Cao, Zichun
collection PubMed
description BACKGROUND: Large prospective studies are essential for investigating the environmental causes of Parkinson’s disease (PD), but PD diagnosis via clinical exams is often infeasible in such studies. OBJECTIVE: To present case ascertainment strategy and data collection in a US cohort of women. METHODS: In the Sister Study (n = 50,884, baseline ages 55.6±9.0), physician-made PD diagnoses were first reported by participants or their proxies. Cohort-wide follow-up surveys collected data on subsequent diagnoses, medication usage and PD-relevant motor and nonmotor symptoms. We contacted self-reported PD cases and their treating physicians to obtain relevant diagnostic and treatment history. Diagnostic adjudication was made via expert review of all available data, except nonmotor symptoms. We examined associations of nonmotor symptoms with incident PD, using multivariable logistic regression models and reported odds ratio (OR) and 95% confidence intervals (CI). RESULTS: Of the 371 potential PD cases identified, 242 diagnoses were confirmed. Compared with unconfirmed cases, confirmed cases were more likely to report PD diagnosis from multiple sources, medication usage, and motor and nonmotor features consistently during the follow-up. PD polygenic risk score was associated with confirmed PD (ORinter-quartile range = 1.74, 95% CI: 1.45–2.10), but not with unconfirmed cases (corresponding OR = 1.05). Hyposmia, dream-enacting behaviors, constipation, depression, unexplained weight loss, dry eyes, dry mouth, and fatigue were significantly related to PD risk, with ORs from 1.71 to 4.88. Only one of the eight negative control symptoms was associated with incident PD. CONCLUSION: Findings support our PD case ascertainment approach in this large cohort of women. PD prodromal presentation is likely beyond its well-documented profile.
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spelling pubmed-104730782023-09-02 Parkinson’s Disease Case Ascertainment in the Sister Study: A Cohort for Environmental Health Research Cao, Zichun Song, Shengfang Huang, Xuemei Li, Chenxi Luo, Zhehui D’Aloisio, Aimee A. Suarez, Lourdes Hernandez, Dena G. Singleton, Andrew B. Sandler, Dale P. Chen, Honglei J Parkinsons Dis Research Article BACKGROUND: Large prospective studies are essential for investigating the environmental causes of Parkinson’s disease (PD), but PD diagnosis via clinical exams is often infeasible in such studies. OBJECTIVE: To present case ascertainment strategy and data collection in a US cohort of women. METHODS: In the Sister Study (n = 50,884, baseline ages 55.6±9.0), physician-made PD diagnoses were first reported by participants or their proxies. Cohort-wide follow-up surveys collected data on subsequent diagnoses, medication usage and PD-relevant motor and nonmotor symptoms. We contacted self-reported PD cases and their treating physicians to obtain relevant diagnostic and treatment history. Diagnostic adjudication was made via expert review of all available data, except nonmotor symptoms. We examined associations of nonmotor symptoms with incident PD, using multivariable logistic regression models and reported odds ratio (OR) and 95% confidence intervals (CI). RESULTS: Of the 371 potential PD cases identified, 242 diagnoses were confirmed. Compared with unconfirmed cases, confirmed cases were more likely to report PD diagnosis from multiple sources, medication usage, and motor and nonmotor features consistently during the follow-up. PD polygenic risk score was associated with confirmed PD (ORinter-quartile range = 1.74, 95% CI: 1.45–2.10), but not with unconfirmed cases (corresponding OR = 1.05). Hyposmia, dream-enacting behaviors, constipation, depression, unexplained weight loss, dry eyes, dry mouth, and fatigue were significantly related to PD risk, with ORs from 1.71 to 4.88. Only one of the eight negative control symptoms was associated with incident PD. CONCLUSION: Findings support our PD case ascertainment approach in this large cohort of women. PD prodromal presentation is likely beyond its well-documented profile. IOS Press 2023-07-25 /pmc/articles/PMC10473078/ /pubmed/37334620 http://dx.doi.org/10.3233/JPD-230053 Text en © 2023 – The authors. Published by IOS Press https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial (CC BY-NC 4.0) License (https://creativecommons.org/licenses/by-nc/4.0/) , which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Cao, Zichun
Song, Shengfang
Huang, Xuemei
Li, Chenxi
Luo, Zhehui
D’Aloisio, Aimee A.
Suarez, Lourdes
Hernandez, Dena G.
Singleton, Andrew B.
Sandler, Dale P.
Chen, Honglei
Parkinson’s Disease Case Ascertainment in the Sister Study: A Cohort for Environmental Health Research
title Parkinson’s Disease Case Ascertainment in the Sister Study: A Cohort for Environmental Health Research
title_full Parkinson’s Disease Case Ascertainment in the Sister Study: A Cohort for Environmental Health Research
title_fullStr Parkinson’s Disease Case Ascertainment in the Sister Study: A Cohort for Environmental Health Research
title_full_unstemmed Parkinson’s Disease Case Ascertainment in the Sister Study: A Cohort for Environmental Health Research
title_short Parkinson’s Disease Case Ascertainment in the Sister Study: A Cohort for Environmental Health Research
title_sort parkinson’s disease case ascertainment in the sister study: a cohort for environmental health research
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10473078/
https://www.ncbi.nlm.nih.gov/pubmed/37334620
http://dx.doi.org/10.3233/JPD-230053
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