Computational Evaluation of Azadirachta indica-Derived Bioactive Compounds as Potential Inhibitors of NLRP3 in the Treatment of Alzheimer’s Disease

BACKGROUND: The development of therapeutic agents against Alzheimer’s disease (AD) has stalled recently. Drug candidates targeting amyloid-β (Aβ) deposition have often failed clinical trials at different stages, prompting the search for novel targets for AD therapy. The NLRP3 inflammasome is an inte...

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Detalles Bibliográficos
Autores principales: Ishabiyi, Felix Oluwasegun, Ogidi, James Okwudirichukwu, Olukade, Baliqis Adejoke, Amorha, Chizoba Christabel, El-Sharkawy, Lina Y., Okolo, Chukwuemeka Calistus, Adeniyi, Titilope Mary, Atasie, Nkechi Hope, Ibrahim, Abdulwasiu, Balogun, Toheeb Adewale
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10473084/
https://www.ncbi.nlm.nih.gov/pubmed/36683510
http://dx.doi.org/10.3233/JAD-221020

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