Weight Change and Neuropsychiatric Symptoms in Alzheimer’s Disease and Frontotemporal Dementia: Associations with Cognitive Decline

Weight changes, neuropsychiatric symptoms (NPS), and cognitive decline often coincide in Alzheimer’s disease (AD) and frontotemporal dementia (FTD); however, the direction of their relationship remains unclear. This study aims to clarify the connection between weight changes, NPS, and cognition in A...

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Detalles Bibliográficos
Autores principales: Morrow, Christopher B., Leoutsakos, Jeannie, Yan, Haijuan, Onyike, Chiadi, Kamath, Vidyulata
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2023
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10473120/
https://www.ncbi.nlm.nih.gov/pubmed/37662607
http://dx.doi.org/10.3233/ADR-230034
Descripción
Sumario:Weight changes, neuropsychiatric symptoms (NPS), and cognitive decline often coincide in Alzheimer’s disease (AD) and frontotemporal dementia (FTD); however, the direction of their relationship remains unclear. This study aims to clarify the connection between weight changes, NPS, and cognition in AD and FTD. We found that cognitive decline was associated with decreased body mass index (BMI) in AD, while BMI gain was associated with increased conversion to FTD. Elevated NPS were associated with decreased BMI in AD and increased BMI in FTD. Identifying early changes in NPS and BMI may facilitate the detection of cognitive decline, providing an opportunity for early intervention.

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