Weight Change and Neuropsychiatric Symptoms in Alzheimer’s Disease and Frontotemporal Dementia: Associations with Cognitive Decline

Weight changes, neuropsychiatric symptoms (NPS), and cognitive decline often coincide in Alzheimer’s disease (AD) and frontotemporal dementia (FTD); however, the direction of their relationship remains unclear. This study aims to clarify the connection between weight changes, NPS, and cognition in A...

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Autores principales: Morrow, Christopher B., Leoutsakos, Jeannie, Yan, Haijuan, Onyike, Chiadi, Kamath, Vidyulata
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2023
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10473120/
https://www.ncbi.nlm.nih.gov/pubmed/37662607
http://dx.doi.org/10.3233/ADR-230034
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author Morrow, Christopher B.
Leoutsakos, Jeannie
Yan, Haijuan
Onyike, Chiadi
Kamath, Vidyulata
author_facet Morrow, Christopher B.
Leoutsakos, Jeannie
Yan, Haijuan
Onyike, Chiadi
Kamath, Vidyulata
author_sort Morrow, Christopher B.
collection PubMed
description Weight changes, neuropsychiatric symptoms (NPS), and cognitive decline often coincide in Alzheimer’s disease (AD) and frontotemporal dementia (FTD); however, the direction of their relationship remains unclear. This study aims to clarify the connection between weight changes, NPS, and cognition in AD and FTD. We found that cognitive decline was associated with decreased body mass index (BMI) in AD, while BMI gain was associated with increased conversion to FTD. Elevated NPS were associated with decreased BMI in AD and increased BMI in FTD. Identifying early changes in NPS and BMI may facilitate the detection of cognitive decline, providing an opportunity for early intervention.
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spelling pubmed-104731202023-09-02 Weight Change and Neuropsychiatric Symptoms in Alzheimer’s Disease and Frontotemporal Dementia: Associations with Cognitive Decline Morrow, Christopher B. Leoutsakos, Jeannie Yan, Haijuan Onyike, Chiadi Kamath, Vidyulata J Alzheimers Dis Rep Short Communication Weight changes, neuropsychiatric symptoms (NPS), and cognitive decline often coincide in Alzheimer’s disease (AD) and frontotemporal dementia (FTD); however, the direction of their relationship remains unclear. This study aims to clarify the connection between weight changes, NPS, and cognition in AD and FTD. We found that cognitive decline was associated with decreased body mass index (BMI) in AD, while BMI gain was associated with increased conversion to FTD. Elevated NPS were associated with decreased BMI in AD and increased BMI in FTD. Identifying early changes in NPS and BMI may facilitate the detection of cognitive decline, providing an opportunity for early intervention. IOS Press 2023-07-24 /pmc/articles/PMC10473120/ /pubmed/37662607 http://dx.doi.org/10.3233/ADR-230034 Text en © 2023 – The authors. Published by IOS Press https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial (CC BY-NC 4.0) License (https://creativecommons.org/licenses/by-nc/4.0/) , which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Communication
Morrow, Christopher B.
Leoutsakos, Jeannie
Yan, Haijuan
Onyike, Chiadi
Kamath, Vidyulata
Weight Change and Neuropsychiatric Symptoms in Alzheimer’s Disease and Frontotemporal Dementia: Associations with Cognitive Decline
title Weight Change and Neuropsychiatric Symptoms in Alzheimer’s Disease and Frontotemporal Dementia: Associations with Cognitive Decline
title_full Weight Change and Neuropsychiatric Symptoms in Alzheimer’s Disease and Frontotemporal Dementia: Associations with Cognitive Decline
title_fullStr Weight Change and Neuropsychiatric Symptoms in Alzheimer’s Disease and Frontotemporal Dementia: Associations with Cognitive Decline
title_full_unstemmed Weight Change and Neuropsychiatric Symptoms in Alzheimer’s Disease and Frontotemporal Dementia: Associations with Cognitive Decline
title_short Weight Change and Neuropsychiatric Symptoms in Alzheimer’s Disease and Frontotemporal Dementia: Associations with Cognitive Decline
title_sort weight change and neuropsychiatric symptoms in alzheimer’s disease and frontotemporal dementia: associations with cognitive decline
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10473120/
https://www.ncbi.nlm.nih.gov/pubmed/37662607
http://dx.doi.org/10.3233/ADR-230034
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