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Mnemonic Discrimination Performance in a Memory Clinic: A Pilot Study
BACKGROUND: Mnemonic discrimination is the behavioral ability stemming from pattern separation, which is the neural process of establishing independent and non-overlapping new memories. Over the past two decades, its assessment in various populations has contributed to a better conceptual understand...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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IOS Press
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10473128/ https://www.ncbi.nlm.nih.gov/pubmed/37458033 http://dx.doi.org/10.3233/JAD-230221 |
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author | Belliart-Guérin, Ghislain Planche, Vincent |
author_facet | Belliart-Guérin, Ghislain Planche, Vincent |
author_sort | Belliart-Guérin, Ghislain |
collection | PubMed |
description | BACKGROUND: Mnemonic discrimination is the behavioral ability stemming from pattern separation, which is the neural process of establishing independent and non-overlapping new memories. Over the past two decades, its assessment in various populations has contributed to a better conceptual understanding of age-related memory decline. OBJECTIVE: To assess the clinical relevance of mnemonic discrimination in the memory clinics setting. METHODS: This retrospective study was performed in 90 patients with a Mini-Mental State Examination (MMSE)>18 who consulted our memory clinic for the first time. All patients were tested with the Mnemonic Similarity Task, a freely available computerized test. Global cognitive function, executive function, visuoconstructional abilities, and verbal and visual episodic memory were also collected, together with the diagnosis after the initial clinical assessment (subjective cognitive complaint [SCC], mild cognitive impairment [MCI], or mild dementia). RESULTS: Mnemonic discrimination performance was correlated with global cognitive function, executive function, and visual and verbal episodic memory scores, independent of age. It discriminated patients with SCC from those with MCI (amnestic or non-amnestic) with moderate accuracy (AUC = 0.77-0.78), similar to MMSE and the Frontal Assessment Battery (AUC = 0.74-0.84). Mnemonic discrimination performance did not distinguish between amnestic and non-amnestic MCI and the variability of the measure was important within groups. CONCLUSION: Mnemonic discrimination performance involves many cognitive domains and discriminates between patients with SCC and MCI with performance equivalent to “paper-and-pencil” screening tests. Further dedicated prospective studies will determine whether this task is of interest beyond research purposes, as a diagnostic or screening tool in primary care. |
format | Online Article Text |
id | pubmed-10473128 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | IOS Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-104731282023-09-02 Mnemonic Discrimination Performance in a Memory Clinic: A Pilot Study Belliart-Guérin, Ghislain Planche, Vincent J Alzheimers Dis Research Article BACKGROUND: Mnemonic discrimination is the behavioral ability stemming from pattern separation, which is the neural process of establishing independent and non-overlapping new memories. Over the past two decades, its assessment in various populations has contributed to a better conceptual understanding of age-related memory decline. OBJECTIVE: To assess the clinical relevance of mnemonic discrimination in the memory clinics setting. METHODS: This retrospective study was performed in 90 patients with a Mini-Mental State Examination (MMSE)>18 who consulted our memory clinic for the first time. All patients were tested with the Mnemonic Similarity Task, a freely available computerized test. Global cognitive function, executive function, visuoconstructional abilities, and verbal and visual episodic memory were also collected, together with the diagnosis after the initial clinical assessment (subjective cognitive complaint [SCC], mild cognitive impairment [MCI], or mild dementia). RESULTS: Mnemonic discrimination performance was correlated with global cognitive function, executive function, and visual and verbal episodic memory scores, independent of age. It discriminated patients with SCC from those with MCI (amnestic or non-amnestic) with moderate accuracy (AUC = 0.77-0.78), similar to MMSE and the Frontal Assessment Battery (AUC = 0.74-0.84). Mnemonic discrimination performance did not distinguish between amnestic and non-amnestic MCI and the variability of the measure was important within groups. CONCLUSION: Mnemonic discrimination performance involves many cognitive domains and discriminates between patients with SCC and MCI with performance equivalent to “paper-and-pencil” screening tests. Further dedicated prospective studies will determine whether this task is of interest beyond research purposes, as a diagnostic or screening tool in primary care. IOS Press 2023-08-15 /pmc/articles/PMC10473128/ /pubmed/37458033 http://dx.doi.org/10.3233/JAD-230221 Text en © 2023 – The authors. Published by IOS Press https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial (CC BY-NC 4.0) License (https://creativecommons.org/licenses/by-nc/4.0/) , which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Belliart-Guérin, Ghislain Planche, Vincent Mnemonic Discrimination Performance in a Memory Clinic: A Pilot Study |
title | Mnemonic Discrimination Performance in a Memory Clinic: A Pilot Study |
title_full | Mnemonic Discrimination Performance in a Memory Clinic: A Pilot Study |
title_fullStr | Mnemonic Discrimination Performance in a Memory Clinic: A Pilot Study |
title_full_unstemmed | Mnemonic Discrimination Performance in a Memory Clinic: A Pilot Study |
title_short | Mnemonic Discrimination Performance in a Memory Clinic: A Pilot Study |
title_sort | mnemonic discrimination performance in a memory clinic: a pilot study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10473128/ https://www.ncbi.nlm.nih.gov/pubmed/37458033 http://dx.doi.org/10.3233/JAD-230221 |
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