Sleep and Circadian Rhythm Dysfunction in Animal Models of Huntington’s Disease

Sleep and circadian disruption affects most individuals with Huntington’s disease (HD) at some stage in their lives. Sleep and circadian dysregulation are also present in many mouse and the sheep models of HD. Here I review evidence for sleep and/or circadian dysfunction in HD transgenic animal mode...

Descripción completa

Detalles Bibliográficos
Autor principal: Morton, A. Jennifer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10473141/
https://www.ncbi.nlm.nih.gov/pubmed/37334613
http://dx.doi.org/10.3233/JHD-230574
Descripción
Sumario:Sleep and circadian disruption affects most individuals with Huntington’s disease (HD) at some stage in their lives. Sleep and circadian dysregulation are also present in many mouse and the sheep models of HD. Here I review evidence for sleep and/or circadian dysfunction in HD transgenic animal models and discuss two key questions: 1) How relevant are such findings to people with HD, and 2) Whether or not therapeutic interventions that ameliorate deficits in animal models of HD might translate to meaningful therapies for people with HD.

Ejemplares similares