Sleep and Circadian Rhythm Dysfunction in Animal Models of Huntington’s Disease

Sleep and circadian disruption affects most individuals with Huntington’s disease (HD) at some stage in their lives. Sleep and circadian dysregulation are also present in many mouse and the sheep models of HD. Here I review evidence for sleep and/or circadian dysfunction in HD transgenic animal mode...

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Detalles Bibliográficos
Autor principal: Morton, A. Jennifer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10473141/
https://www.ncbi.nlm.nih.gov/pubmed/37334613
http://dx.doi.org/10.3233/JHD-230574
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author Morton, A. Jennifer
author_facet Morton, A. Jennifer
author_sort Morton, A. Jennifer
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description Sleep and circadian disruption affects most individuals with Huntington’s disease (HD) at some stage in their lives. Sleep and circadian dysregulation are also present in many mouse and the sheep models of HD. Here I review evidence for sleep and/or circadian dysfunction in HD transgenic animal models and discuss two key questions: 1) How relevant are such findings to people with HD, and 2) Whether or not therapeutic interventions that ameliorate deficits in animal models of HD might translate to meaningful therapies for people with HD.
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spelling pubmed-104731412023-09-02 Sleep and Circadian Rhythm Dysfunction in Animal Models of Huntington’s Disease Morton, A. Jennifer J Huntingtons Dis Review Sleep and circadian disruption affects most individuals with Huntington’s disease (HD) at some stage in their lives. Sleep and circadian dysregulation are also present in many mouse and the sheep models of HD. Here I review evidence for sleep and/or circadian dysfunction in HD transgenic animal models and discuss two key questions: 1) How relevant are such findings to people with HD, and 2) Whether or not therapeutic interventions that ameliorate deficits in animal models of HD might translate to meaningful therapies for people with HD. IOS Press 2023-07-28 /pmc/articles/PMC10473141/ /pubmed/37334613 http://dx.doi.org/10.3233/JHD-230574 Text en © 2023 – The authors. Published by IOS Press https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial (CC BY-NC 4.0) License (https://creativecommons.org/licenses/by-nc/4.0/) , which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Morton, A. Jennifer
Sleep and Circadian Rhythm Dysfunction in Animal Models of Huntington’s Disease
title Sleep and Circadian Rhythm Dysfunction in Animal Models of Huntington’s Disease
title_full Sleep and Circadian Rhythm Dysfunction in Animal Models of Huntington’s Disease
title_fullStr Sleep and Circadian Rhythm Dysfunction in Animal Models of Huntington’s Disease
title_full_unstemmed Sleep and Circadian Rhythm Dysfunction in Animal Models of Huntington’s Disease
title_short Sleep and Circadian Rhythm Dysfunction in Animal Models of Huntington’s Disease
title_sort sleep and circadian rhythm dysfunction in animal models of huntington’s disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10473141/
https://www.ncbi.nlm.nih.gov/pubmed/37334613
http://dx.doi.org/10.3233/JHD-230574
work_keys_str_mv AT mortonajennifer sleepandcircadianrhythmdysfunctioninanimalmodelsofhuntingtonsdisease

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